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• W2013655951 abstract "Pulmonary arterial hypertension (PAH) is a progressive and lethal disease that has a strong female predominance, often affecting the young. Current therapies are mostly vasodilator agents, and while mainly addressing the endothelial dysfunction that has been widely reported in this disease, they may be less effective in treating arterial remodeling. The lung pathology of PAH is characterized by medial hypertrophy and intimal hyperplasia of muscular arteries as well as plexiform lesions, that lead to a widespread narrowing or obliteration of the pulmonary arteriolar bed. However, the pathogenesis of the functional and structural abnormalities of the lung microcirculation in PAH is poorly understood. Perhaps the greatest advancement in the last decade has been the discovery of the “PAH gene,” bone morphogenetic receptor 2 (Bmpr2), however how the loss-of-function mutations in Bmpr2 lead to PAH is unclear. The BMPR2 pathway has recently been shown to mediate survival signaling in endothelial cells (EC), and thus the reduced activity will favor endothelial apoptosis, likely increasing the susceptibility to endothelial injury in response to various environmental triggers. EC apoptosis has been implicated as an initiating event in experimental PAH, leading either directly to the degeneration of pre-capillary arterioles or to the selection of hyperproliferative, apoptosis-resistant ECs that may contribute to “angioproliferative” plexiform lesions. The idea that EC apoptosis may play a central role in the initiation and progression of PAH suggests that therapeutic strategies aimed at endothelial repair and regeneration of ECs may be uniquely effective in the treatment of this disease. Preclinical evaluation and validation on the use of endothelial progenitor cells (EPCs) for the prevention and reversal of experimental PAH is reviewed and the design of a “first in man” clinical trial to assess the safety and efficacy of a combined EPC and endothelial NO-synthase gene therapy for patients that are refractory to standard therapies is discussed." @default.
• W2013655951 created "2016-06-24" @default.
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• W2013655951 date "2010-04-01" @default.
• W2013655951 modified "2023-10-13" @default.
• W2013655951 title "Role of apoptosis in pulmonary hypertension: From experimental models to clinical trials" @default.
• W2013655951 cites W1482672078 @default.
• W2013655951 cites W1606441445 @default.
• W2013655951 cites W1976505539 @default.
• W2013655951 cites W1979954254 @default.
• W2013655951 cites W1981443796 @default.
• W2013655951 cites W1983741275 @default.
• W2013655951 cites W1987821958 @default.
• W2013655951 cites W1994324715 @default.
• W2013655951 cites W1996588278 @default.
• W2013655951 cites W1997715331 @default.
• W2013655951 cites W2000228053 @default.
• W2013655951 cites W2009029293 @default.
• W2013655951 cites W2015814205 @default.
• W2013655951 cites W2025947830 @default.
• W2013655951 cites W2027712474 @default.
• W2013655951 cites W2030470655 @default.
• W2013655951 cites W2035523654 @default.
• W2013655951 cites W2039172749 @default.
• W2013655951 cites W2039818367 @default.
• W2013655951 cites W204164459 @default.
• W2013655951 cites W2042430449 @default.
• W2013655951 cites W2044920093 @default.
• W2013655951 cites W2052774423 @default.
• W2013655951 cites W2067413933 @default.
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• W2013655951 cites W2093943199 @default.
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• W2013655951 cites W2136960837 @default.
• W2013655951 cites W2139347037 @default.
• W2013655951 cites W2139960175 @default.
• W2013655951 cites W2146234408 @default.
• W2013655951 cites W2146730628 @default.
• W2013655951 cites W2146966841 @default.
• W2013655951 cites W2150480894 @default.
• W2013655951 cites W2151475873 @default.
• W2013655951 cites W2152501741 @default.
• W2013655951 cites W2153224916 @default.
• W2013655951 cites W2162125686 @default.
• W2013655951 cites W2166207482 @default.
• W2013655951 cites W2167788252 @default.
• W2013655951 cites W2169047384 @default.
• W2013655951 cites W2169289228 @default.
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• W2013655951 doi "https://doi.org/10.1016/j.pharmthera.2009.12.006" @default.
• W2013655951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20117135" @default.
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