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- W2013661041 abstract "Analgesia induced by nitrous oxide was examined using radiant heat tail flick and electrical evoked foot flick tests in rats. Rats exposed to 80 and 60% nitrous oxide expressed statistically significant elevations of percent analgesia (% MPE) compared to air exposed rats. Rats exposed to 30% nitrous oxide showed no significant difference in percent analgesia. Pretreatment with naloxone (10 mg/kg s.c.) produced a significant decrease in %MPE and an increase in variance of response after exposures to 80% nitrous oxide in a double blind study. Kainic acid lesions of the ventral and caudal periaqueductal grey (PAG) reversed analgesia produced by 80% nitrous oxide in a crossover blink study compared to saline lesions. In conclusion, this evidence suggests that the caudal-PAG-raphe mangus-dorsal horn pain inhibition pathway is in part involved in the analgesia induced by nitrous oxide." @default.
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- W2013661041 title "Nitrous oxide analgesia: partial antagonism by naloxone and total reversal after periaqueductal gray lesions in the rat" @default.
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- W2013661041 doi "https://doi.org/10.1016/0014-2999(87)90653-4" @default.
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