FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013661706> ?p ?o ?g. }

• W2013661706 endingPage "8256" @default.
• W2013661706 startingPage "8239" @default.
• W2013661706 abstract "Apurinic/apyrimidinic endonuclease 1 (APE1), an essential protein in mammals, is involved in base excision DNA repair (BER) and in regulation of gene expression, acting as a redox co-activator of several transcription factors. Recent findings highlight a novel role for APE1 in RNA metabolism, which is modulated by nucleophosmin (NPM1). The results reported in this article show that five lysine residues (K24, K25, K27, K31 and K32), located in the APE1 N-terminal unstructured domain, are involved in the interaction of APE1 with both RNA and NPM1, thus supporting a competitive binding mechanism. Data from kinetic experiments demonstrate that the APE1 N-terminal domain also serves as a device for fine regulation of protein catalytic activity on abasic DNA. Interestingly, some of these critical lysine residues undergo acetylation in vivo. These results suggest that protein–protein interactions and/or post-translational modifications involving APE1 N-terminal domain may play important in vivo roles, in better coordinating and fine-tuning protein BER activity and function on RNA metabolism." @default.
• W2013661706 created "2016-06-24" @default.
• W2013661706 creator A5025839745 @default.
• W2013661706 creator A5029443104 @default.
• W2013661706 creator A5031985588 @default.
• W2013661706 creator A5034323784 @default.
• W2013661706 creator A5039440705 @default.
• W2013661706 creator A5047004590 @default.
• W2013661706 creator A5048971494 @default.
• W2013661706 creator A5054729027 @default.
• W2013661706 creator A5055943955 @default.
• W2013661706 creator A5058608501 @default.
• W2013661706 creator A5078680549 @default.
• W2013661706 creator A5079083947 @default.
• W2013661706 creator A5083586476 @default.
• W2013661706 date "2010-08-10" @default.
• W2013661706 modified "2023-10-06" @default.
• W2013661706 title "Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions" @default.
• W2013661706 cites W1965398768 @default.
• W2013661706 cites W1968895302 @default.
• W2013661706 cites W1969030243 @default.
• W2013661706 cites W1971577441 @default.
• W2013661706 cites W1972241251 @default.
• W2013661706 cites W1986493103 @default.
• W2013661706 cites W1991374720 @default.
• W2013661706 cites W1994594217 @default.
• W2013661706 cites W1999125434 @default.
• W2013661706 cites W1999440327 @default.
• W2013661706 cites W2001866617 @default.
• W2013661706 cites W2006952521 @default.
• W2013661706 cites W2012033459 @default.
• W2013661706 cites W2016065650 @default.
• W2013661706 cites W2016170088 @default.
• W2013661706 cites W2019829180 @default.
• W2013661706 cites W2019954113 @default.
• W2013661706 cites W2020781844 @default.
• W2013661706 cites W2028494787 @default.
• W2013661706 cites W2034003930 @default.
• W2013661706 cites W2035807710 @default.
• W2013661706 cites W2037455416 @default.
• W2013661706 cites W2042367379 @default.
• W2013661706 cites W2042723688 @default.
• W2013661706 cites W2053573382 @default.
• W2013661706 cites W2055043387 @default.
• W2013661706 cites W2057987846 @default.
• W2013661706 cites W2067961610 @default.
• W2013661706 cites W2070759617 @default.
• W2013661706 cites W2071523470 @default.
• W2013661706 cites W2073887708 @default.
• W2013661706 cites W2082829202 @default.
• W2013661706 cites W2085397858 @default.
• W2013661706 cites W2086870723 @default.
• W2013661706 cites W2089126898 @default.
• W2013661706 cites W2092235774 @default.
• W2013661706 cites W2098910355 @default.
• W2013661706 cites W2100904609 @default.
• W2013661706 cites W2109979991 @default.
• W2013661706 cites W2119345428 @default.
• W2013661706 cites W2119362018 @default.
• W2013661706 cites W2120993848 @default.
• W2013661706 cites W2125121305 @default.
• W2013661706 cites W2136995982 @default.
• W2013661706 cites W2138569524 @default.
• W2013661706 cites W2150266021 @default.
• W2013661706 cites W2162874229 @default.
• W2013661706 cites W2164539951 @default.
• W2013661706 cites W2165788169 @default.
• W2013661706 cites W2166775631 @default.
• W2013661706 cites W2171758261 @default.
• W2013661706 doi "https://doi.org/10.1093/nar/gkq691" @default.
• W2013661706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3001066" @default.
• W2013661706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20699270" @default.
• W2013661706 hasPublicationYear "2010" @default.
• W2013661706 type Work @default.
• W2013661706 sameAs 2013661706 @default.
• W2013661706 citedByCount "99" @default.
• W2013661706 countsByYear W20136617062012 @default.
• W2013661706 countsByYear W20136617062013 @default.
• W2013661706 countsByYear W20136617062014 @default.
• W2013661706 countsByYear W20136617062015 @default.
• W2013661706 countsByYear W20136617062016 @default.
• W2013661706 countsByYear W20136617062017 @default.
• W2013661706 countsByYear W20136617062018 @default.
• W2013661706 countsByYear W20136617062019 @default.
• W2013661706 countsByYear W20136617062020 @default.
• W2013661706 countsByYear W20136617062021 @default.
• W2013661706 countsByYear W20136617062022 @default.
• W2013661706 countsByYear W20136617062023 @default.
• W2013661706 crossrefType "journal-article" @default.
• W2013661706 hasAuthorship W2013661706A5025839745 @default.
• W2013661706 hasAuthorship W2013661706A5029443104 @default.
• W2013661706 hasAuthorship W2013661706A5031985588 @default.
• W2013661706 hasAuthorship W2013661706A5034323784 @default.
• W2013661706 hasAuthorship W2013661706A5039440705 @default.
• W2013661706 hasAuthorship W2013661706A5047004590 @default.
• W2013661706 hasAuthorship W2013661706A5048971494 @default.
• W2013661706 hasAuthorship W2013661706A5054729027 @default.
• W2013661706 hasAuthorship W2013661706A5055943955 @default.

• next