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- W2013663106 abstract "After confirming that adrenalectomy per se does not affect skeletal muscle protein synthesis rates, we examined whether endogenously produced glucocorticoids modulate the effect of physiological insulin concentrations on protein synthesis in overnight-fasted rats 4 days after either a bilateral adrenalectomy (ADX), ADX with dexamethasone treatment (ADX + DEX), or a sham operation (Sham; n = 6 each). Rats received a 3-h euglycemic insulin clamp (3 mU · min −1 · kg −1 ). Rectus muscle protein synthesis was measured at the end of the clamp, and the phosphorylation states of protein kinase B (Akt), eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), and ribosomal protein S6 kinase (p70 S6K ) were quantitated before and after the insulin clamp. The basal phosphorylation states of Akt, 4E-BP1, and p70 S6K were similar between ADX and Sham rats. Insulin significantly enhanced the phosphorylation of Akt ( P < 0.03), 4E-BP1 ( P = 0.003), and p70 S6K ( P < 0.002) in ADX but not in Sham rats. Protein synthesis was significantly greater after insulin infusion in ADX than in Sham rats ( P = 0.01). Glucocorticoid replacement blunted the effect of insulin on Akt, 4E-BP1, and p70 S6K phosphorylation and protein synthesis. In conclusion, glucocorticoid deficiency enhances the insulin sensitivity of muscle protein synthesis, which is mediated by increased phosphorylation of translation initiation-regulatory proteins." @default.
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- W2013663106 date "2003-01-01" @default.
- W2013663106 modified "2023-10-12" @default.
- W2013663106 title "Adrenalectomy enhances the insulin sensitivity of muscle protein synthesis" @default.
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- W2013663106 doi "https://doi.org/10.1152/ajpendo.00028.2002" @default.
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