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• W2013664313 abstract "Significance Inositol pyrophosphates are messenger molecules incorporating the energetic pyrophosphate bond. Although they have been implicated in diverse biologic processes, their physiologic functions remain enigmatic. We show that the catalytic activity of inositol hexakisphosphate kinase 2 (IP6K2), one of the principal enzymes generating the inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate), mediates cancer cell migration and tumor metastasis both in cell culture and intact mice. In this process, IP6K2 diminishes cell–cell adhesion, enabling cells to invade the intercellular matrix. Drugs that inhibit IP6K2 may be beneficial in cancer therapy." @default.
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• W2013664313 date "2015-01-23" @default.
• W2013664313 modified "2023-10-16" @default.
• W2013664313 title "Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1" @default.
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• W2013664313 doi "https://doi.org/10.1073/pnas.1424642112" @default.
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