FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013668219> ?p ?o ?g. }

• W2013668219 endingPage "944" @default.
• W2013668219 startingPage "935" @default.
• W2013668219 abstract "Rationale: Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) has been implicated as a maladaptive mediator of cardiac ischemic injury. We hypothesized that the inflammatory response associated with in vivo ischemia/reperfusion (I/R) is initiated through CaMKII signaling. Objective: To assess the contribution of CaMKIIδ to the development of inflammation, infarct, and ventricular dysfunction after in vivo I/R and define early cardiomyocyte–autonomous events regulated by CaMKIIδ using cardiac-specific knockout mice. Methods and Results: Wild-type and CaMKIIδ knockout mice were subjected to in vivo I/R by occlusion of the left anterior descending artery for 1 hour followed by reperfusion for various times. CaMKIIδ deletion protected the heart against I/R damage as evidenced by decreased infarct size, attenuated apoptosis, and improved functional recovery. CaMKIIδ deletion also attenuated I/R-induced inflammation and upregulation of nuclear factor-κB (NF-κB) target genes. Further studies demonstrated that I/R rapidly increases CaMKII activity, leading to NF-κB activation within minutes of reperfusion. Experiments using cyclosporine A and cardiac-specific CaMKIIδ knockout mice indicate that NF-κB activation is initiated independent of necrosis and within cardiomyocytes. Expression of activated CaMKII in cardiomyocytes leads to IκB kinase phosphorylation and concomitant increases in nuclear p65. Experiments using an IκB kinase inhibitor support the conclusion that this is a proximal site of CaMKII-mediated NF-κB activation. Conclusions: This is the first study demonstrating that CaMKIIδ mediates NF-κB activation in cardiomyocytes after in vivo I/R and suggests that CaMKIIδ serves to trigger, as well as to sustain subsequent changes in inflammatory gene expression that contribute to myocardial I/R damage." @default.
• W2013668219 created "2016-06-24" @default.
• W2013668219 creator A5013084636 @default.
• W2013668219 creator A5033696938 @default.
• W2013668219 creator A5036278362 @default.
• W2013668219 creator A5037087448 @default.
• W2013668219 creator A5045287779 @default.
• W2013668219 creator A5075485431 @default.
• W2013668219 creator A5079543238 @default.
• W2013668219 creator A5087269715 @default.
• W2013668219 creator A5090820164 @default.
• W2013668219 date "2013-03-15" @default.
• W2013668219 modified "2023-10-16" @default.
• W2013668219 title "Ca ²⁺ /Calmodulin-Dependent Protein Kinase II δ Mediates Myocardial Ischemia/Reperfusion Injury Through Nuclear Factor-κB" @default.
• W2013668219 cites W1504410512 @default.
• W2013668219 cites W1600368065 @default.
• W2013668219 cites W1634129492 @default.
• W2013668219 cites W1965301431 @default.
• W2013668219 cites W1974408946 @default.
• W2013668219 cites W2001261561 @default.
• W2013668219 cites W2015053221 @default.
• W2013668219 cites W2026385570 @default.
• W2013668219 cites W2029707564 @default.
• W2013668219 cites W2034978016 @default.
• W2013668219 cites W2047231225 @default.
• W2013668219 cites W2049665768 @default.
• W2013668219 cites W2054898931 @default.
• W2013668219 cites W2056668196 @default.
• W2013668219 cites W2056679835 @default.
• W2013668219 cites W2063932784 @default.
• W2013668219 cites W2074294483 @default.
• W2013668219 cites W2075936537 @default.
• W2013668219 cites W2079113729 @default.
• W2013668219 cites W2079670268 @default.
• W2013668219 cites W2091583229 @default.
• W2013668219 cites W2097068525 @default.
• W2013668219 cites W2099093659 @default.
• W2013668219 cites W2102349921 @default.
• W2013668219 cites W2107544067 @default.
• W2013668219 cites W2107933519 @default.
• W2013668219 cites W2112223772 @default.
• W2013668219 cites W2113488772 @default.
• W2013668219 cites W2117571600 @default.
• W2013668219 cites W2126464451 @default.
• W2013668219 cites W2126472646 @default.
• W2013668219 cites W2136098553 @default.
• W2013668219 cites W2148230219 @default.
• W2013668219 cites W2158240381 @default.
• W2013668219 cites W2399414035 @default.
• W2013668219 doi "https://doi.org/10.1161/circresaha.112.276915" @default.
• W2013668219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3673710" @default.
• W2013668219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23388157" @default.
• W2013668219 hasPublicationYear "2013" @default.
• W2013668219 type Work @default.
• W2013668219 sameAs 2013668219 @default.
• W2013668219 citedByCount "138" @default.
• W2013668219 countsByYear W20136682192012 @default.
• W2013668219 countsByYear W20136682192013 @default.
• W2013668219 countsByYear W20136682192014 @default.
• W2013668219 countsByYear W20136682192015 @default.
• W2013668219 countsByYear W20136682192016 @default.
• W2013668219 countsByYear W20136682192017 @default.
• W2013668219 countsByYear W20136682192018 @default.
• W2013668219 countsByYear W20136682192019 @default.
• W2013668219 countsByYear W20136682192020 @default.
• W2013668219 countsByYear W20136682192021 @default.
• W2013668219 countsByYear W20136682192022 @default.
• W2013668219 countsByYear W20136682192023 @default.
• W2013668219 crossrefType "journal-article" @default.
• W2013668219 hasAuthorship W2013668219A5013084636 @default.
• W2013668219 hasAuthorship W2013668219A5033696938 @default.
• W2013668219 hasAuthorship W2013668219A5036278362 @default.
• W2013668219 hasAuthorship W2013668219A5037087448 @default.
• W2013668219 hasAuthorship W2013668219A5045287779 @default.
• W2013668219 hasAuthorship W2013668219A5075485431 @default.
• W2013668219 hasAuthorship W2013668219A5079543238 @default.
• W2013668219 hasAuthorship W2013668219A5087269715 @default.
• W2013668219 hasAuthorship W2013668219A5090820164 @default.
• W2013668219 hasBestOaLocation W20136682191 @default.
• W2013668219 hasConcept C104317684 @default.
• W2013668219 hasConcept C11960822 @default.
• W2013668219 hasConcept C126322002 @default.
• W2013668219 hasConcept C127561419 @default.
• W2013668219 hasConcept C134018914 @default.
• W2013668219 hasConcept C150903083 @default.
• W2013668219 hasConcept C170493617 @default.
• W2013668219 hasConcept C182704531 @default.
• W2013668219 hasConcept C184235292 @default.
• W2013668219 hasConcept C185592680 @default.
• W2013668219 hasConcept C207001950 @default.
• W2013668219 hasConcept C2776914184 @default.
• W2013668219 hasConcept C2777730290 @default.
• W2013668219 hasConcept C2779730028 @default.
• W2013668219 hasConcept C2780114680 @default.
• W2013668219 hasConcept C29688787 @default.
• W2013668219 hasConcept C519063684 @default.
• W2013668219 hasConcept C541997718 @default.
• W2013668219 hasConcept C55493867 @default.

• next