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- W2013669397 endingPage "437" @default.
- W2013669397 startingPage "437" @default.
- W2013669397 abstract "Mitochondria are cell organelles mostly known for their production of ATP through oxidative phosphorylation. As suggested over 70 years ago by O. Warburg and recently confirmed with molecular techniques, alterations in respiratory activity and mitochondrial DNA appear to be a common feature of malignant cells. Somatic mtDNA mutations have been reported in many types of cancer cells. MtDNA mutation pattern may enhance the specificity of cancer diagnostics, detection and prediction of tumor growth rate and patients' outcome. Therefore it may be used as a molecular cancer bio-marker. Nevertheless recently published papers list a large number of mitochondrial DNA mutations in many different cancer types, but their role in cell pathophysiology remains unsummarized. This review covers the consequences of mitochondrial genes mutations for human cell physiology and proliferation. We underline effects of mtDNA mutation-resulting amino acid changes in the respiratory chain proteins' structure, and propose changes in mitochondrial protein function. Mutations are critically evaluated and interpreted in the functional context and clinical utility of molecular mitochondrial research is summarized and new perspectives for 'mitochondrial oncology' suggested." @default.
- W2013669397 created "2016-06-24" @default.
- W2013669397 creator A5010625425 @default.
- W2013669397 creator A5040046990 @default.
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- W2013669397 creator A5050178891 @default.
- W2013669397 creator A5061132159 @default.
- W2013669397 creator A5089930164 @default.
- W2013669397 date "2010-01-01" @default.
- W2013669397 modified "2023-10-16" @default.
- W2013669397 title "Mitochondrial DNA mutations in cancer - from bench to bedside" @default.
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