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• W2013669949 abstract "<h3>Context</h3> Preterm very low-birth-weight (VLBW) infants have a high prevalence of neurodevelopmental disability when evaluated during the first several years of life. However, recent experimental data suggest that the developing brain may recover from or compensate for injury. <h3>Objective</h3> To determine if there is cognitive improvement throughout early and middle childhood following VLBW birth. <h3>Design, Setting, and Participants</h3> Follow-up data of 296 infants born weighing 600 to 1250 g who participated in a prospective, randomized, placebo-controlled intraventricular hemorrhage (IVH) prevention study performed at 3 northeastern US hospitals between September 1989 and August 1992 and who were serially evaluated at 36, 54, 72, and 96 months of corrected age (CA). <h3>Main Outcome Measures</h3> The age-normed Peabody Picture Vocabulary Test–Revised (PPVT-R) score and measures of intelligence. <h3>Results</h3> Overall, the median PPVT-R score increased from 88 at 36 months of CA to 99 at 96 months of CA; when data from 36 and 96 months of CA were compared, 45% of children gained 10 points or more and 12.5% showed a 5- to 9-point increase in test scores. Similar findings were noted for full-scale and verbal IQ scores. Multivariate analyses demonstrated that increasing age, residence in a 2-parent household, and higher levels of maternal education were all significantly associated with higher PPVT-R scores (for each,<i>P</i><.001). In addition, early intervention led to greater increases over time in PPVT-R scores among children whose mothers had less than a high school education compared with those with a high school education level or greater (<i>P</i>= .03 by test for interaction). Although most children showed improvement in PPVT-R scores with increasing CA, children with early-onset IVH and subsequent significant central nervous system injury had the lowest PPVT-R scores initially and the scores declined over time (<i>P</i>= .009 by test for interaction). <h3>Conclusions</h3> The majority of VLBW children had improvement in verbal and IQ test scores over time. Only children with early-onset IVH followed by significant central nervous system injury had low PPVT-R scores that declined over time." @default.
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• W2013669949 date "2003-02-12" @default.
• W2013669949 modified "2023-10-12" @default.
• W2013669949 title "Change in Cognitive Function Over Time in Very Low-Birth-Weight Infants" @default.
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• W2013669949 doi "https://doi.org/10.1001/jama.289.6.705" @default.
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