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- W2013670173 abstract "Albuminuria is closely associated with stroke and cardiovascular diseases (CVDs) as well as the salt sensitivity of blood pressure (BP). Although albuminuria may reflect generalized endothelial dysfunction, there may be more specific hemodynamic mechanisms underlying these associations. Cerebral hemorrhage and infarction occur most frequently in the area of small perforating arteries that are exposed to high pressure and that have to maintain strong vascular tone in order to provide large pressure gradients from the parent vessels to the capillaries. Analogous to the perforating arteries are the glomerular afferent arterioles of the juxtamedullary nephrons. Hypertensive vascular damage occurs first and more severely in the juxtamedullary glomeruli. Therefore, albuminuria may be an early sign of vascular damages imposed on ‘strain vessels’ such as perforating arteries and juxtamedullary afferent arterioles. Coronary circulation also occurs under unique hemodynamic conditions, in which the entire epicardial segments are exposed to very high pressure with little flow during systolic phases. From the evolutionary point of view, we speculate that such circulatory systems in the vital organs are mandatory for survival under the danger of hypoperfusion due to difficult access to salt and water as well as high risks of wound injuries. In addition, albuminuria would indicate an impairment of renal medullary circulation, downstream from the juxtamedullary glomeruli, and therefore an impaired pressure natriuresis, which would lead to salt sensitivity of BP. Our ‘strain vessel hypothesis’ may explain why hypertension and diabetes, unforeseen in the concept of evolution, preferentially affect vital organs such as the brain, heart and kidney." @default.
- W2013670173 created "2016-06-24" @default.
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- W2013670173 date "2009-01-16" @default.
- W2013670173 modified "2023-10-12" @default.
- W2013670173 title "Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk" @default.
- W2013670173 cites W1601794155 @default.
- W2013670173 cites W1964923088 @default.
- W2013670173 cites W1965261569 @default.
- W2013670173 cites W1965778644 @default.
- W2013670173 cites W1967448769 @default.
- W2013670173 cites W1967610947 @default.
- W2013670173 cites W1973746251 @default.
- W2013670173 cites W1979815847 @default.
- W2013670173 cites W1981643883 @default.
- W2013670173 cites W1982728207 @default.
- W2013670173 cites W1983077746 @default.
- W2013670173 cites W1984037141 @default.
- W2013670173 cites W1988036809 @default.
- W2013670173 cites W1998381684 @default.
- W2013670173 cites W1999316094 @default.
- W2013670173 cites W2009767037 @default.
- W2013670173 cites W2012487082 @default.
- W2013670173 cites W2013811855 @default.
- W2013670173 cites W2020635815 @default.
- W2013670173 cites W2024967196 @default.
- W2013670173 cites W2026555733 @default.
- W2013670173 cites W2028053632 @default.
- W2013670173 cites W2028067282 @default.
- W2013670173 cites W2030791307 @default.
- W2013670173 cites W2031789966 @default.
- W2013670173 cites W2033149201 @default.
- W2013670173 cites W2034530918 @default.
- W2013670173 cites W2035402278 @default.
- W2013670173 cites W2038435240 @default.
- W2013670173 cites W2046809996 @default.
- W2013670173 cites W2047092132 @default.
- W2013670173 cites W2048489466 @default.
- W2013670173 cites W2061136592 @default.
- W2013670173 cites W2061145694 @default.
- W2013670173 cites W2062661134 @default.
- W2013670173 cites W2068579932 @default.
- W2013670173 cites W2081448458 @default.
- W2013670173 cites W2096875294 @default.
- W2013670173 cites W2098839081 @default.
- W2013670173 cites W2099981978 @default.
- W2013670173 cites W2100268343 @default.
- W2013670173 cites W2103235855 @default.
- W2013670173 cites W2103868761 @default.
- W2013670173 cites W2106863400 @default.
- W2013670173 cites W2107031719 @default.
- W2013670173 cites W2108446898 @default.
- W2013670173 cites W2108595845 @default.
- W2013670173 cites W2109595776 @default.
- W2013670173 cites W2111142862 @default.
- W2013670173 cites W2112407228 @default.
- W2013670173 cites W2113552111 @default.
- W2013670173 cites W2114068048 @default.
- W2013670173 cites W2114925922 @default.
- W2013670173 cites W2116612438 @default.
- W2013670173 cites W2117801955 @default.
- W2013670173 cites W2119313387 @default.
- W2013670173 cites W2120638470 @default.
- W2013670173 cites W2123831918 @default.
- W2013670173 cites W2136106925 @default.
- W2013670173 cites W2145984957 @default.
- W2013670173 cites W2146571866 @default.
- W2013670173 cites W2147672592 @default.
- W2013670173 cites W2152043519 @default.
- W2013670173 cites W2156101232 @default.
- W2013670173 cites W2160440319 @default.
- W2013670173 cites W2166484078 @default.
- W2013670173 cites W2168287443 @default.
- W2013670173 cites W2170753465 @default.
- W2013670173 cites W2171329003 @default.
- W2013670173 cites W2275546552 @default.
- W2013670173 cites W2316259688 @default.
- W2013670173 cites W2324579467 @default.
- W2013670173 cites W2326173193 @default.
- W2013670173 cites W2328141787 @default.
- W2013670173 cites W2338372639 @default.
- W2013670173 cites W2392101321 @default.
- W2013670173 cites W2488868277 @default.
- W2013670173 cites W2618462878 @default.
- W2013670173 cites W2939337927 @default.
- W2013670173 cites W4234040478 @default.
- W2013670173 cites W4248116761 @default.
- W2013670173 cites W4382891181 @default.
- W2013670173 cites W80391022 @default.
- W2013670173 doi "https://doi.org/10.1038/hr.2008.27" @default.
- W2013670173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19262469" @default.
- W2013670173 hasPublicationYear "2009" @default.
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