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- W2013670253 abstract "When Cytotherapy was fi rst published, cell therapy was restricted to the use of hematopoietic stem cells (HSC), lymphocytes and dendritic cells. Since then we have witnessed an explosion in the discovery of diverse stem cells and progenitors capable of differentiating into almost any body tissue. This special ‘ In Focus ’ issue highlights seven papers from research centers around the world that collectively describe an ever-widening family of tissue-resident progenitors with stem cell properties, the techniques to differentiate them into a diversity of cell types and the process of good manufacturing practice (GMP)-grade manufacture of such progenitors. Pasquinelli et al. (1) have identifi ed a mesenchymal cell in the vascular wall of the human aorta. Expression of CD105 and CD90, and the absence of CD45, CD34, VWF and CD31, identifi ed it as a mesenchymal stromal cell (MSC), while expression of Stro-1, Notch-1 and Oct-4 and the ability to form a spheroid showed it had stem cell-like properties. These cells differentiated into smooth muscle cells and endothelial cells, fulfi lling the criteria for a resident cell with the ability to repair damage in large blood vessels. Their relationship with vascular pericytes is not clear, nor is the relative contribution to repair of these so-called ‘ multidistrict vascular wall MSC ’ versus circulating progenitors with regenerative properties, such as HSC, MSC and endothelial cells. This raises questions for repair strategies: how useful and effective are circulating cells, and if they cannot reach the site of injury how can the potential of the resident cells be unlocked to correct the damage? Working with progenitor cells in the pancreatic islets in the rat, Karaoz et al. (2) searched for a progenitor that could renew pancreatic islets. They describe a CD105 , vimentin , CD31 – , CD34 – and CD45 – MSC with stem cell properties (spheroid formation, Oct-4, Sox and REX expression). This MSC therefore appears to be more primitive and stem cell-like than bone marrow MSC. These cells had the ability to" @default.
- W2013670253 created "2016-06-24" @default.
- W2013670253 creator A5001195277 @default.
- W2013670253 date "2010-01-01" @default.
- W2013670253 modified "2023-09-25" @default.
- W2013670253 title "A profusion of progenitors" @default.
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- W2013670253 doi "https://doi.org/10.3109/14653241003778947" @default.
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