FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013670373> ?p ?o ?g. }

• W2013670373 endingPage "e79098" @default.
• W2013670373 startingPage "e79098" @default.
• W2013670373 abstract "The protozoan parasite Leishmania major causes cutaneous lesions to develop at the site of infection, which are resolved with a strong Th1 immune response in resistant hosts, such as C57BL/6 mice. In contrast, the lesions ulcerate in susceptible hosts which display a Th2 response, such as BALB/c mice. The migration of cells in the immune response to L. major is regulated by chemokines and their receptors. The chemokine receptor CCR7 is expressed on activated DCs and naïve T cells, allowing them to migrate to the correct micro-anatomical positions within secondary lymphoid organs. While there have been many studies on the function of CCR7 during homeostasis or using model antigens, there are very few studies on the role of CCR7 during infection. In this study, we show that B6.CCR7-/- mice were unable to resolve the lesion and developed a chronic disease. The composition of the local infiltrate at the lesion was significantly skewed toward neutrophils while the proportion of CCR2+ monocytes was reduced. Furthermore, a greater percentage of CCR2+ monocytes expressed CCR7 in the footpad than in the lymph node or spleen of B6.WT mice. We also found an increased percentage of regulatory T cells in the draining lymph node of B6.CCR7-/- mice throughout infection. Additionally, the cytokine milieu of the lymph node showed a Th2 bias, rather than the resistant Th1 phenotype. This data shows that CCR7 is required for a protective immune response to intracellular L. major infection." @default.
• W2013670373 created "2016-06-24" @default.
• W2013670373 creator A5034338988 @default.
• W2013670373 creator A5077716691 @default.
• W2013670373 creator A5085709802 @default.
• W2013670373 date "2013-10-30" @default.
• W2013670373 modified "2023-09-27" @default.
• W2013670373 title "The Absence of CCR7 Results in Dysregulated Monocyte Migration and Immunosuppression Facilitating Chronic Cutaneous Leishmaniasis" @default.
• W2013670373 cites W1481092164 @default.
• W2013670373 cites W1501500713 @default.
• W2013670373 cites W1501511128 @default.
• W2013670373 cites W1519859357 @default.
• W2013670373 cites W1823625017 @default.
• W2013670373 cites W1863279221 @default.
• W2013670373 cites W1920534265 @default.
• W2013670373 cites W1965778779 @default.
• W2013670373 cites W1965913368 @default.
• W2013670373 cites W1967994686 @default.
• W2013670373 cites W1981480494 @default.
• W2013670373 cites W1983600034 @default.
• W2013670373 cites W1992943210 @default.
• W2013670373 cites W2002063813 @default.
• W2013670373 cites W2003566453 @default.
• W2013670373 cites W2004468695 @default.
• W2013670373 cites W2006238268 @default.
• W2013670373 cites W2008202534 @default.
• W2013670373 cites W2012628829 @default.
• W2013670373 cites W2026487158 @default.
• W2013670373 cites W2039134318 @default.
• W2013670373 cites W2041765961 @default.
• W2013670373 cites W2042945702 @default.
• W2013670373 cites W2055260998 @default.
• W2013670373 cites W2059410321 @default.
• W2013670373 cites W2067648924 @default.
• W2013670373 cites W2080847266 @default.
• W2013670373 cites W2082014233 @default.
• W2013670373 cites W2082224040 @default.
• W2013670373 cites W2087726988 @default.
• W2013670373 cites W2097208739 @default.
• W2013670373 cites W2097296981 @default.
• W2013670373 cites W2099144412 @default.
• W2013670373 cites W2100349623 @default.
• W2013670373 cites W2101351790 @default.
• W2013670373 cites W2120986025 @default.
• W2013670373 cites W2121018520 @default.
• W2013670373 cites W2121602730 @default.
• W2013670373 cites W2121835123 @default.
• W2013670373 cites W2125600524 @default.
• W2013670373 cites W2127278205 @default.
• W2013670373 cites W2135703618 @default.
• W2013670373 cites W2135925682 @default.
• W2013670373 cites W2138780833 @default.
• W2013670373 cites W2143762644 @default.
• W2013670373 cites W2148806075 @default.
• W2013670373 cites W2153264962 @default.
• W2013670373 cites W2154483825 @default.
• W2013670373 cites W2155779547 @default.
• W2013670373 cites W2158108669 @default.
• W2013670373 cites W2161074777 @default.
• W2013670373 cites W2162149101 @default.
• W2013670373 cites W2163693304 @default.
• W2013670373 cites W2165299403 @default.
• W2013670373 cites W2168930459 @default.
• W2013670373 cites W2172466148 @default.
• W2013670373 cites W2317145780 @default.
• W2013670373 cites W4248565951 @default.
• W2013670373 cites W97158386 @default.
• W2013670373 doi "https://doi.org/10.1371/journal.pone.0079098" @default.
• W2013670373 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3813618" @default.
• W2013670373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24205367" @default.
• W2013670373 hasPublicationYear "2013" @default.
• W2013670373 type Work @default.
• W2013670373 sameAs 2013670373 @default.
• W2013670373 citedByCount "12" @default.
• W2013670373 countsByYear W20136703732017 @default.
• W2013670373 countsByYear W20136703732018 @default.
• W2013670373 countsByYear W20136703732019 @default.
• W2013670373 countsByYear W20136703732020 @default.
• W2013670373 countsByYear W20136703732021 @default.
• W2013670373 countsByYear W20136703732023 @default.
• W2013670373 crossrefType "journal-article" @default.
• W2013670373 hasAuthorship W2013670373A5034338988 @default.
• W2013670373 hasAuthorship W2013670373A5077716691 @default.
• W2013670373 hasAuthorship W2013670373A5085709802 @default.
• W2013670373 hasBestOaLocation W20136703731 @default.
• W2013670373 hasConcept C127801297 @default.
• W2013670373 hasConcept C12823836 @default.
• W2013670373 hasConcept C128879288 @default.
• W2013670373 hasConcept C13373296 @default.
• W2013670373 hasConcept C136764020 @default.
• W2013670373 hasConcept C203014093 @default.
• W2013670373 hasConcept C2776555147 @default.
• W2013670373 hasConcept C2778702967 @default.
• W2013670373 hasConcept C2780599195 @default.
• W2013670373 hasConcept C2780849966 @default.
• W2013670373 hasConcept C2781092759 @default.
• W2013670373 hasConcept C41008148 @default.
• W2013670373 hasConcept C71928629 @default.

• next