FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013670547> ?p ?o ?g. }

• W2013670547 endingPage "445" @default.
• W2013670547 startingPage "429" @default.
• W2013670547 abstract "The effects of octyltrimethylammonium ions (OTMA+), octyl sulphate ions (OS-) and octanoic acid (OA) on the sodium current of the voltage-clamped squid giant axon have been investigated using intracellular and extracellular application of the test substances. OTMA+ applied externally at concentrations of 0.8-5.0 mM produces a small reversible increase in the peak inward sodium current in both intact and CsF-perfused axons. Intracellular application of OTMA+ at 0.8 mM to CsF-perfused axons causes a reversible 50% suppression of peak inward sodium current. The inhibition of peak inward current by internal OTMA+ arises largely from a shift of the steady-state activation parameter (m infinity) in the depolarizing direction along the voltage axis. There is little use dependence of the current suppression by OTMA+ OA applied either internally or externally is more effective at suppressing peak inward sodium current at pH 6.0 than at pH 7.4. At pH 6.0 external application of 5 mM-OA to perfused axons causes approximately 60% suppression. This is associated with a depolarizing shift of m infinity of about 13 mV and a hyperpolarizing shift of the steady-state inactivation (h infinity) curve of about 4 mV. The effects of internal and external OA are broadly similar except that the h infinity shift is not seen with internal application. OS- at concentrations above 2.0 mM produces complete irreversible loss of sodium current. At 2.0 mM, OS- produces 10% current suppression and a small depolarizing shift of the m infinity curve. Internal and external applications of OS- differ little except that external OS- causes a 25% increase in the time constant of activation (tau m). The possible origins of these effects are discussed. It is proposed that the shift of m infinity caused by internal OTMA+ is due to a diminution of the lipid dipole potential at the internal surface of the membrane caused by OTMA+ adsorption. This effect could also account for the m infinity shift caused by OA. The results showing that OA produces shifts of opposite sign in the voltage dependence of m infinity and h infinity are discussed with respect to their implications for models of sodium channel gating." @default.
• W2013670547 created "2016-06-24" @default.
• W2013670547 creator A5033165020 @default.
• W2013670547 creator A5081303458 @default.
• W2013670547 creator A5087052002 @default.
• W2013670547 date "1984-05-01" @default.
• W2013670547 modified "2023-09-25" @default.
• W2013670547 title "The asymmetrical effects of some ionized n-octyl derivatives on the sodium current of the giant axon of Loligo forbesi." @default.
• W2013670547 cites W1661187373 @default.
• W2013670547 cites W1974700237 @default.
• W2013670547 cites W1975611540 @default.
• W2013670547 cites W1985940938 @default.
• W2013670547 cites W2000017434 @default.
• W2013670547 cites W2003486597 @default.
• W2013670547 cites W2021148049 @default.
• W2013670547 cites W2025141399 @default.
• W2013670547 cites W2028274352 @default.
• W2013670547 cites W2035637382 @default.
• W2013670547 cites W2052857850 @default.
• W2013670547 cites W2062507442 @default.
• W2013670547 cites W2063959378 @default.
• W2013670547 cites W2069283356 @default.
• W2013670547 cites W2070233250 @default.
• W2013670547 cites W2076538889 @default.
• W2013670547 cites W2086622488 @default.
• W2013670547 cites W2088049591 @default.
• W2013670547 cites W2092323759 @default.
• W2013670547 cites W2093173175 @default.
• W2013670547 cites W2112882990 @default.
• W2013670547 cites W2116411564 @default.
• W2013670547 cites W2128819954 @default.
• W2013670547 cites W2129072751 @default.
• W2013670547 cites W2150142099 @default.
• W2013670547 cites W2153061500 @default.
• W2013670547 cites W2167509313 @default.
• W2013670547 cites W2922816857 @default.
• W2013670547 doi "https://doi.org/10.1113/jphysiol.1984.sp015210" @default.
• W2013670547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1199278" @default.
• W2013670547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6747855" @default.
• W2013670547 hasPublicationYear "1984" @default.
• W2013670547 type Work @default.
• W2013670547 sameAs 2013670547 @default.
• W2013670547 citedByCount "24" @default.
• W2013670547 crossrefType "journal-article" @default.
• W2013670547 hasAuthorship W2013670547A5033165020 @default.
• W2013670547 hasAuthorship W2013670547A5081303458 @default.
• W2013670547 hasAuthorship W2013670547A5087052002 @default.
• W2013670547 hasBestOaLocation W20136705472 @default.
• W2013670547 hasConcept C105702510 @default.
• W2013670547 hasConcept C121332964 @default.
• W2013670547 hasConcept C12554922 @default.
• W2013670547 hasConcept C147789679 @default.
• W2013670547 hasConcept C148043351 @default.
• W2013670547 hasConcept C178790620 @default.
• W2013670547 hasConcept C185592680 @default.
• W2013670547 hasConcept C2779530196 @default.
• W2013670547 hasConcept C28406088 @default.
• W2013670547 hasConcept C4141045 @default.
• W2013670547 hasConcept C50952357 @default.
• W2013670547 hasConcept C537181965 @default.
• W2013670547 hasConcept C55493867 @default.
• W2013670547 hasConcept C79879829 @default.
• W2013670547 hasConcept C8171440 @default.
• W2013670547 hasConcept C86803240 @default.
• W2013670547 hasConcept C97355855 @default.
• W2013670547 hasConceptScore W2013670547C105702510 @default.
• W2013670547 hasConceptScore W2013670547C121332964 @default.
• W2013670547 hasConceptScore W2013670547C12554922 @default.
• W2013670547 hasConceptScore W2013670547C147789679 @default.
• W2013670547 hasConceptScore W2013670547C148043351 @default.
• W2013670547 hasConceptScore W2013670547C178790620 @default.
• W2013670547 hasConceptScore W2013670547C185592680 @default.
• W2013670547 hasConceptScore W2013670547C2779530196 @default.
• W2013670547 hasConceptScore W2013670547C28406088 @default.
• W2013670547 hasConceptScore W2013670547C4141045 @default.
• W2013670547 hasConceptScore W2013670547C50952357 @default.
• W2013670547 hasConceptScore W2013670547C537181965 @default.
• W2013670547 hasConceptScore W2013670547C55493867 @default.
• W2013670547 hasConceptScore W2013670547C79879829 @default.
• W2013670547 hasConceptScore W2013670547C8171440 @default.
• W2013670547 hasConceptScore W2013670547C86803240 @default.
• W2013670547 hasConceptScore W2013670547C97355855 @default.
• W2013670547 hasIssue "1" @default.
• W2013670547 hasLocation W20136705471 @default.
• W2013670547 hasLocation W20136705472 @default.
• W2013670547 hasLocation W20136705473 @default.
• W2013670547 hasOpenAccess W2013670547 @default.
• W2013670547 hasPrimaryLocation W20136705471 @default.
• W2013670547 hasRelatedWork W1595962221 @default.
• W2013670547 hasRelatedWork W2033418219 @default.
• W2013670547 hasRelatedWork W2068406497 @default.
• W2013670547 hasRelatedWork W2069564982 @default.
• W2013670547 hasRelatedWork W2097710660 @default.
• W2013670547 hasRelatedWork W2123369785 @default.
• W2013670547 hasRelatedWork W2135452620 @default.
• W2013670547 hasRelatedWork W2141534959 @default.
• W2013670547 hasRelatedWork W2339794357 @default.
• W2013670547 hasRelatedWork W2914884256 @default.

• next