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- W2013670589 abstract "Abstract 1.1. Patients with pernicious anemia in relapse have been studied as examples of vitamin B 12 -depleted subjects. A critical study of the minimal dosage of parenterally administered vitamin B 12 required for initial response and the long-term maintenance of these patients has been made. From these data estimates of the dietary requirement of vitamin B 12 have been derived. 2.2. The data on initial response and on maintenance consistently indicate a daily utilization of vitamin B 12 ranging from 0.5 to 2.0 μg., the more usual range being 0.5 to 1.0 μg. Considering the efficiency of absorption by normal persons of quantities of this order of vitamin B 12 we estimate that the minimal daily dietary needs for this vitamin may be met by approximately 0.6 to 2.8 μg., with a narrower range of 0.6 to 1.2 μg. sufficient for most persons. 3.3. Long-term observations on patients receiving smaller than minimal dosage indicate that the demands of vitamin B 12 for hemopoiesis exceed those for other clinically recognized physiologic functions, and that macrocytosis is the most sensitive indicator of vitamin B 12 deficiency. In appraising vitamin B 12 nutriture careful estimates of erythrocyte size therefore are important." @default.
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- W2013670589 date "1958-11-01" @default.
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- W2013670589 title "Vitamin B12 requirement of adult man" @default.
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- W2013670589 doi "https://doi.org/10.1016/0002-9343(58)90010-x" @default.
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