FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013672945> ?p ?o ?g. }

• W2013672945 endingPage "14691" @default.
• W2013672945 startingPage "14683" @default.
• W2013672945 abstract "Understanding the issue of specificity imposed in the interactions of SH3 domains has largely been addressed in studies investigating the interaction of proline-rich amino acid sequences derived from potential ligands for these domains. Although the interaction with this motif forms an essential platform in the binding of SH3 domains, in many cases little specificity is observed and the difference in affinity for so-called specific and nonspecific proline-rich sequences is not great. Furthermore, the binding interface between an SH3 domain and a protein ligand appears to encompass more interactions than are represented by that involving the proline-rich motif. Here we investigate the issue of specificity from the opposite point of view; namely, how does a ligand recognize different SH3 domains? We present the crystal structure of the unbound SH3 domain from hemopoietic cell kinase (Hck) which is a member of the Src family of tyrosine kinases. This structure reveals that, unlike the structures of other Src kinase SH3 domains, the RT loop region is highly mobile and lacks a network of hydrogen bonds that is elsewhere apparent. The RT loop has been shown to form a major part of the binding interface between SH3 domains and HIV-1 Nef. Thermodynamic data, derived from isothermal titration calorimetry, for the binding of Hck SH3 to HIV-1 Nef show that the binding of Hck (KD = 1.5 μM) is approximately an order of magnitude tighter than those of other Src family kinases that were investigated (Fyn, Lck, and Src). This increase in affinity is attributed to, among other effects, the inherent flexibility in the RT loop which does not require breaking the network of hydrogen bonds to adopt the conformation required for binding." @default.
• W2013672945 created "2016-06-24" @default.
• W2013672945 creator A5003575872 @default.
• W2013672945 creator A5026037696 @default.
• W2013672945 creator A5051843836 @default.
• W2013672945 creator A5057051999 @default.
• W2013672945 creator A5063494613 @default.
• W2013672945 creator A5075017116 @default.
• W2013672945 creator A5075378774 @default.
• W2013672945 date "1998-10-01" @default.
• W2013672945 modified "2023-10-16" @default.
• W2013672945 title "RT Loop Flexibility Enhances the Specificity of Src Family SH3 Domains for HIV-1 Nef^," @default.
• W2013672945 cites W1522400918 @default.
• W2013672945 cites W1923801572 @default.
• W2013672945 cites W1986191025 @default.
• W2013672945 cites W1992739911 @default.
• W2013672945 cites W2000840258 @default.
• W2013672945 cites W2016207825 @default.
• W2013672945 cites W2020357919 @default.
• W2013672945 cites W2080476827 @default.
• W2013672945 cites W2093381148 @default.
• W2013672945 cites W2097508364 @default.
• W2013672945 cites W2164939655 @default.
• W2013672945 cites W326168881 @default.
• W2013672945 cites W4293226720 @default.
• W2013672945 cites W62276193 @default.
• W2013672945 doi "https://doi.org/10.1021/bi980989q" @default.
• W2013672945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9778343" @default.
• W2013672945 hasPublicationYear "1998" @default.
• W2013672945 type Work @default.
• W2013672945 sameAs 2013672945 @default.
• W2013672945 citedByCount "112" @default.
• W2013672945 countsByYear W20136729452012 @default.
• W2013672945 countsByYear W20136729452013 @default.
• W2013672945 countsByYear W20136729452014 @default.
• W2013672945 countsByYear W20136729452015 @default.
• W2013672945 countsByYear W20136729452016 @default.
• W2013672945 countsByYear W20136729452019 @default.
• W2013672945 countsByYear W20136729452020 @default.
• W2013672945 countsByYear W20136729452021 @default.
• W2013672945 countsByYear W20136729452022 @default.
• W2013672945 countsByYear W20136729452023 @default.
• W2013672945 crossrefType "journal-article" @default.
• W2013672945 hasAuthorship W2013672945A5003575872 @default.
• W2013672945 hasAuthorship W2013672945A5026037696 @default.
• W2013672945 hasAuthorship W2013672945A5051843836 @default.
• W2013672945 hasAuthorship W2013672945A5057051999 @default.
• W2013672945 hasAuthorship W2013672945A5063494613 @default.
• W2013672945 hasAuthorship W2013672945A5075017116 @default.
• W2013672945 hasAuthorship W2013672945A5075378774 @default.
• W2013672945 hasBestOaLocation W20136729453 @default.
• W2013672945 hasConcept C107824862 @default.
• W2013672945 hasConcept C108636557 @default.
• W2013672945 hasConcept C109300003 @default.
• W2013672945 hasConcept C156911925 @default.
• W2013672945 hasConcept C184235292 @default.
• W2013672945 hasConcept C185592680 @default.
• W2013672945 hasConcept C196347352 @default.
• W2013672945 hasConcept C2779281246 @default.
• W2013672945 hasConcept C42362537 @default.
• W2013672945 hasConcept C51639874 @default.
• W2013672945 hasConcept C55493867 @default.
• W2013672945 hasConcept C62478195 @default.
• W2013672945 hasConcept C86803240 @default.
• W2013672945 hasConceptScore W2013672945C107824862 @default.
• W2013672945 hasConceptScore W2013672945C108636557 @default.
• W2013672945 hasConceptScore W2013672945C109300003 @default.
• W2013672945 hasConceptScore W2013672945C156911925 @default.
• W2013672945 hasConceptScore W2013672945C184235292 @default.
• W2013672945 hasConceptScore W2013672945C185592680 @default.
• W2013672945 hasConceptScore W2013672945C196347352 @default.
• W2013672945 hasConceptScore W2013672945C2779281246 @default.
• W2013672945 hasConceptScore W2013672945C42362537 @default.
• W2013672945 hasConceptScore W2013672945C51639874 @default.
• W2013672945 hasConceptScore W2013672945C55493867 @default.
• W2013672945 hasConceptScore W2013672945C62478195 @default.
• W2013672945 hasConceptScore W2013672945C86803240 @default.
• W2013672945 hasIssue "42" @default.
• W2013672945 hasLocation W20136729451 @default.
• W2013672945 hasLocation W20136729452 @default.
• W2013672945 hasLocation W20136729453 @default.
• W2013672945 hasLocation W20136729454 @default.
• W2013672945 hasLocation W20136729455 @default.
• W2013672945 hasLocation W20136729456 @default.
• W2013672945 hasLocation W20136729457 @default.
• W2013672945 hasOpenAccess W2013672945 @default.
• W2013672945 hasPrimaryLocation W20136729451 @default.
• W2013672945 hasRelatedWork W1485667500 @default.
• W2013672945 hasRelatedWork W1967448808 @default.
• W2013672945 hasRelatedWork W1990516841 @default.
• W2013672945 hasRelatedWork W2022201177 @default.
• W2013672945 hasRelatedWork W2037130336 @default.
• W2013672945 hasRelatedWork W2085011027 @default.
• W2013672945 hasRelatedWork W2093878568 @default.
• W2013672945 hasRelatedWork W2095097248 @default.
• W2013672945 hasRelatedWork W2125591567 @default.
• W2013672945 hasRelatedWork W3085911573 @default.
• W2013672945 hasVolume "37" @default.

• next