FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013674733> ?p ?o ?g. }

• W2013674733 endingPage "156" @default.
• W2013674733 startingPage "147" @default.
• W2013674733 abstract "Plasma concentrations of the hormone gastrin are elevated by Helicobacter pylori infection and by gastric atrophy. It has previously been proposed that gastrin acts as a cofactor during gastric carcinogenesis and hypergastrinemic transgenic INS-GAS mice are prone to developing gastric adenocarcinoma, particularly following H. pylori infection. We hypothesised that the increased risk of carcinogenesis in these animals may partly result from altered susceptibility of gastric epithelial cells to undergo apoptosis. Gastric corpus apoptosis was significantly increased 48 h after 12Gy γ-radiation in mice rendered hypergastrinemic by transgenic (INS-GAS) or pharmacological (omeprazole treatment of FVB/N mice) methods and in both cases the effects were inhibited by the CCK-2 receptor antagonist YM022. However, no alteration in susceptibility to γ-radiation-induced gastric epithelial apoptosis was observed in mice overexpressing progastrin or glycine-extended gastrin. Apoptosis was also significantly increased in gastric corpus biopsies obtained from H. pylori-infected humans with moderate degrees of hypergastrinemia. We conclude that hypergastrinemia specifically renders cells within the gastric corpus epithelium more susceptible to induction of apoptosis by radiation or H. pylori. Altered susceptibility to apoptosis may therefore be one factor predisposing to gastric carcinogenesis in INS-GAS mice and similar mechanisms may also be involved in humans." @default.
• W2013674733 created "2016-06-24" @default.
• W2013674733 creator A5011502399 @default.
• W2013674733 creator A5017389570 @default.
• W2013674733 creator A5033056161 @default.
• W2013674733 creator A5034242696 @default.
• W2013674733 creator A5043039140 @default.
• W2013674733 creator A5074984612 @default.
• W2013674733 creator A5086541938 @default.
• W2013674733 date "2008-02-01" @default.
• W2013674733 modified "2023-10-17" @default.
• W2013674733 title "Hypergastrinemia increases gastric epithelial susceptibility to apoptosis" @default.
• W2013674733 cites W1967511524 @default.
• W2013674733 cites W1973141163 @default.
• W2013674733 cites W1998530387 @default.
• W2013674733 cites W2005690646 @default.
• W2013674733 cites W2015333344 @default.
• W2013674733 cites W2020219664 @default.
• W2013674733 cites W2022018558 @default.
• W2013674733 cites W2023938188 @default.
• W2013674733 cites W2027507003 @default.
• W2013674733 cites W2035163301 @default.
• W2013674733 cites W2042205173 @default.
• W2013674733 cites W2052448284 @default.
• W2013674733 cites W2060588069 @default.
• W2013674733 cites W2064225392 @default.
• W2013674733 cites W2066400312 @default.
• W2013674733 cites W2075021269 @default.
• W2013674733 cites W2076694998 @default.
• W2013674733 cites W2077502013 @default.
• W2013674733 cites W2090241102 @default.
• W2013674733 cites W2099221981 @default.
• W2013674733 cites W2108335763 @default.
• W2013674733 cites W2111417076 @default.
• W2013674733 cites W2124624578 @default.
• W2013674733 cites W2125428966 @default.
• W2013674733 cites W2142805203 @default.
• W2013674733 cites W2143175781 @default.
• W2013674733 cites W2143745748 @default.
• W2013674733 cites W2152314991 @default.
• W2013674733 cites W2170966889 @default.
• W2013674733 doi "https://doi.org/10.1016/j.regpep.2007.09.002" @default.
• W2013674733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17900712" @default.
• W2013674733 hasPublicationYear "2008" @default.
• W2013674733 type Work @default.
• W2013674733 sameAs 2013674733 @default.
• W2013674733 citedByCount "29" @default.
• W2013674733 countsByYear W20136747332012 @default.
• W2013674733 countsByYear W20136747332013 @default.
• W2013674733 countsByYear W20136747332014 @default.
• W2013674733 countsByYear W20136747332015 @default.
• W2013674733 countsByYear W20136747332016 @default.
• W2013674733 countsByYear W20136747332020 @default.
• W2013674733 countsByYear W20136747332022 @default.
• W2013674733 crossrefType "journal-article" @default.
• W2013674733 hasAuthorship W2013674733A5011502399 @default.
• W2013674733 hasAuthorship W2013674733A5017389570 @default.
• W2013674733 hasAuthorship W2013674733A5033056161 @default.
• W2013674733 hasAuthorship W2013674733A5034242696 @default.
• W2013674733 hasAuthorship W2013674733A5043039140 @default.
• W2013674733 hasAuthorship W2013674733A5074984612 @default.
• W2013674733 hasAuthorship W2013674733A5086541938 @default.
• W2013674733 hasConcept C121608353 @default.
• W2013674733 hasConcept C126322002 @default.
• W2013674733 hasConcept C134018914 @default.
• W2013674733 hasConcept C186199130 @default.
• W2013674733 hasConcept C190283241 @default.
• W2013674733 hasConcept C2776409635 @default.
• W2013674733 hasConcept C2776986829 @default.
• W2013674733 hasConcept C2779422922 @default.
• W2013674733 hasConcept C2781443798 @default.
• W2013674733 hasConcept C49039625 @default.
• W2013674733 hasConcept C502942594 @default.
• W2013674733 hasConcept C55493867 @default.
• W2013674733 hasConcept C555283112 @default.
• W2013674733 hasConcept C71924100 @default.
• W2013674733 hasConcept C86803240 @default.
• W2013674733 hasConceptScore W2013674733C121608353 @default.
• W2013674733 hasConceptScore W2013674733C126322002 @default.
• W2013674733 hasConceptScore W2013674733C134018914 @default.
• W2013674733 hasConceptScore W2013674733C186199130 @default.
• W2013674733 hasConceptScore W2013674733C190283241 @default.
• W2013674733 hasConceptScore W2013674733C2776409635 @default.
• W2013674733 hasConceptScore W2013674733C2776986829 @default.
• W2013674733 hasConceptScore W2013674733C2779422922 @default.
• W2013674733 hasConceptScore W2013674733C2781443798 @default.
• W2013674733 hasConceptScore W2013674733C49039625 @default.
• W2013674733 hasConceptScore W2013674733C502942594 @default.
• W2013674733 hasConceptScore W2013674733C55493867 @default.
• W2013674733 hasConceptScore W2013674733C555283112 @default.
• W2013674733 hasConceptScore W2013674733C71924100 @default.
• W2013674733 hasConceptScore W2013674733C86803240 @default.
• W2013674733 hasIssue "1-3" @default.
• W2013674733 hasLocation W20136747331 @default.
• W2013674733 hasLocation W20136747332 @default.
• W2013674733 hasOpenAccess W2013674733 @default.
• W2013674733 hasPrimaryLocation W20136747331 @default.
• W2013674733 hasRelatedWork W172860144 @default.

• next