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• W2013676248 abstract "The classification, morphology and function of enteric neurons have been extensively studied in the small and large intestine. However, little is known about enteric neurons that directly project to the CNS. Previous studies have identified these unique neurons in the rectum, rectospinal neurons, but little was done to characterize them. Therefore, the aim of this study was to identify and characterize enteric neurons in the rat colon that directly project to the CNS by using retrograde neuronal tracing and immunohistochemistry. By applying the retrograde tracers 1,1′-dioctadecyl-3,3,3′,3′-tetramethyl-indocarbocyanine perchlorate (DiI) and Fluorogold (FG) to the L6/S1 segments of the spinal cord, we identified these neurons in both the myenteric and submucosal plexuses of the colon. These neurons were immunoreactive for neurofilament (NF) a marker for Aδ-fibers and isolectin-B4 (IB4) a marker for C-fibers. These neurons expressed the enzyme neuronal nitric oxide synthase (nNOS) as well as peptides associated with sensory neurons such as substance P (SP) and vasoactive intestinal polypeptide (VIP) but did not express calcitonin gene-related peptide (CGRP). The N-methyl-d-aspartate (NMDA) receptor subunits NR1 and NR2D and proteinase-activated receptor-2 (PAR2) were also found in these neurons. However they did not express the transient receptor potential receptor V1 (TRPV1) or neurokinin 1 receptor (NK1). The expression of the peptides and receptors suggests that there are at least two separate populations of neurons projecting from the colon to the CNS. The data suggest that these colospinal afferent neurons (CANs) might be involved in nociception. Whether sensory information from CANs is perceived by the animal or is part of the parasympathetic reflex is currently not known." @default.
• W2013676248 created "2016-06-24" @default.
• W2013676248 creator A5039547941 @default.
• W2013676248 creator A5076675384 @default.
• W2013676248 date "2008-05-01" @default.
• W2013676248 modified "2023-10-03" @default.
• W2013676248 title "Identification and immunohistochemical characterization of colospinal afferent neurons in the rat" @default.
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• W2013676248 doi "https://doi.org/10.1016/j.neuroscience.2008.02.046" @default.
• W2013676248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8073176" @default.
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