FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013678879> ?p ?o ?g. }

• W2013678879 endingPage "2321" @default.
• W2013678879 startingPage "2316" @default.
• W2013678879 abstract "The success of molecular targeted therapy in cancer may depend on the selection of appropriate tumor types whose survival depends on the drug target, so-called “oncogene addiction.” Preclinical approaches to defining drug-responsive subsets are needed if initial clinical trials are to be directed at the most susceptible patient population. Here, we show that gastric cancer cells with high-level stable chromosomal amplification of the growth factor receptor MET are extraordinarily susceptible to the selective inhibitor PHA-665752. Although MET activation has primarily been linked with tumor cell migration and invasiveness, the amplified wild-type MET in these cells is constitutively activated, and its continued signaling is required for cell survival. Treatment with PHA-665752 triggers massive apoptosis in 5 of 5 gastric cancer cell lines with MET amplification but in 0 of 12 without increased gene copy numbers ( P = 0.00016). MET amplification may thus identify a subset of epithelial cancers that are uniquely sensitive to disruption of this pathway and define a patient group that is appropriate for clinical trials of targeted therapy using MET inhibitors." @default.
• W2013678879 created "2016-06-24" @default.
• W2013678879 creator A5004579069 @default.
• W2013678879 creator A5014650726 @default.
• W2013678879 creator A5019396643 @default.
• W2013678879 creator A5022736367 @default.
• W2013678879 creator A5034256147 @default.
• W2013678879 creator A5038280749 @default.
• W2013678879 creator A5046054897 @default.
• W2013678879 creator A5046992202 @default.
• W2013678879 creator A5050226985 @default.
• W2013678879 creator A5057777319 @default.
• W2013678879 creator A5074923974 @default.
• W2013678879 creator A5079911644 @default.
• W2013678879 creator A5086227121 @default.
• W2013678879 date "2006-02-06" @default.
• W2013678879 modified "2023-10-05" @default.
• W2013678879 title "Amplification of <i>MET</i> may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752" @default.
• W2013678879 cites W1967405376 @default.
• W2013678879 cites W1985229759 @default.
• W2013678879 cites W1992563018 @default.
• W2013678879 cites W2013112408 @default.
• W2013678879 cites W2013739293 @default.
• W2013678879 cites W2016710415 @default.
• W2013678879 cites W2019573100 @default.
• W2013678879 cites W2029353164 @default.
• W2013678879 cites W2043696829 @default.
• W2013678879 cites W2048142144 @default.
• W2013678879 cites W2049274590 @default.
• W2013678879 cites W2064698668 @default.
• W2013678879 cites W2070241543 @default.
• W2013678879 cites W2073140732 @default.
• W2013678879 cites W2082735583 @default.
• W2013678879 cites W2087352606 @default.
• W2013678879 cites W2103894337 @default.
• W2013678879 cites W2110835998 @default.
• W2013678879 cites W2120718661 @default.
• W2013678879 cites W2125730396 @default.
• W2013678879 cites W2127101185 @default.
• W2013678879 cites W2137390717 @default.
• W2013678879 cites W2139236349 @default.
• W2013678879 cites W2141393790 @default.
• W2013678879 cites W2146404049 @default.
• W2013678879 cites W2150501295 @default.
• W2013678879 cites W2153764234 @default.
• W2013678879 cites W2161821474 @default.
• W2013678879 cites W2329648702 @default.
• W2013678879 cites W2400986674 @default.
• W2013678879 cites W4243379377 @default.
• W2013678879 doi "https://doi.org/10.1073/pnas.0508776103" @default.
• W2013678879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1413705" @default.
• W2013678879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16461907" @default.
• W2013678879 hasPublicationYear "2006" @default.
• W2013678879 type Work @default.
• W2013678879 sameAs 2013678879 @default.
• W2013678879 citedByCount "465" @default.
• W2013678879 countsByYear W20136788792012 @default.
• W2013678879 countsByYear W20136788792013 @default.
• W2013678879 countsByYear W20136788792014 @default.
• W2013678879 countsByYear W20136788792015 @default.
• W2013678879 countsByYear W20136788792016 @default.
• W2013678879 countsByYear W20136788792017 @default.
• W2013678879 countsByYear W20136788792018 @default.
• W2013678879 countsByYear W20136788792019 @default.
• W2013678879 countsByYear W20136788792020 @default.
• W2013678879 countsByYear W20136788792021 @default.
• W2013678879 countsByYear W20136788792022 @default.
• W2013678879 countsByYear W20136788792023 @default.
• W2013678879 crossrefType "journal-article" @default.
• W2013678879 hasAuthorship W2013678879A5004579069 @default.
• W2013678879 hasAuthorship W2013678879A5014650726 @default.
• W2013678879 hasAuthorship W2013678879A5019396643 @default.
• W2013678879 hasAuthorship W2013678879A5022736367 @default.
• W2013678879 hasAuthorship W2013678879A5034256147 @default.
• W2013678879 hasAuthorship W2013678879A5038280749 @default.
• W2013678879 hasAuthorship W2013678879A5046054897 @default.
• W2013678879 hasAuthorship W2013678879A5046992202 @default.
• W2013678879 hasAuthorship W2013678879A5050226985 @default.
• W2013678879 hasAuthorship W2013678879A5057777319 @default.
• W2013678879 hasAuthorship W2013678879A5074923974 @default.
• W2013678879 hasAuthorship W2013678879A5079911644 @default.
• W2013678879 hasAuthorship W2013678879A5086227121 @default.
• W2013678879 hasBestOaLocation W20136788791 @default.
• W2013678879 hasConcept C101544691 @default.
• W2013678879 hasConcept C104317684 @default.
• W2013678879 hasConcept C121608353 @default.
• W2013678879 hasConcept C170493617 @default.
• W2013678879 hasConcept C2781018059 @default.
• W2013678879 hasConcept C2908647359 @default.
• W2013678879 hasConcept C29537977 @default.
• W2013678879 hasConcept C42362537 @default.
• W2013678879 hasConcept C502942594 @default.
• W2013678879 hasConcept C54355233 @default.
• W2013678879 hasConcept C71924100 @default.
• W2013678879 hasConcept C7602840 @default.
• W2013678879 hasConcept C86803240 @default.
• W2013678879 hasConcept C96232424 @default.
• W2013678879 hasConcept C99454951 @default.

• next