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- W2013678982 abstract "The synthesis of six hexapeptide analogues of C-terminal Substance P fragment containing alpha, beta-dehydrophenylalanine (delta Phe) in the position 7 or 8 is described. The effect of the structural changes on the hypotensive activity and antigenic properties of analogues was compared. It was found that substitution of delta Phe in various analogues of C-terminal hexapeptide of Substance P resulted in different effects on the hypotensive activity. The analogues [Glp6, delta Phe7]SP6-11 and [Glp6, delta Phe8]SP6-11 retained 70% and 45% of hypotensive activity of the C-terminal hexapeptide of Substance P, respectively but they showed a completely destroyed antigenic determinant. The analogues containing additionally Sar or His in the position 9 showed a complete lack of both: hypotensive activity and expression of the antigenic determinant of Substance P." @default.
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- W2013678982 date "1987-06-01" @default.
- W2013678982 modified "2023-09-27" @default.
- W2013678982 title "Synthesis and biological activity of Substance P C-terminal hexapeptide analogues: Structure-activity studies" @default.
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- W2013678982 doi "https://doi.org/10.1016/0006-291x(87)91056-4" @default.
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