Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013687768> ?p ?o ?g. }
- W2013687768 abstract "The anti-cancer effects of metformin, the most widely used drug for type 2 diabetes, alone or in combination with ionizing radiation were studied with MCF-7 human breast cancer cells and FSaII mouse fibrosarcoma cells. Clinically achievable concentrations of metformin caused significant clonogenic death in cancer cells. Importantly, metformin was preferentially cytotoxic to cancer stem cells relative to non-cancer stem cells. Metformin increased the radiosensitivity of cancer cells in vitro and significantly enhanced the radiation-induced growth delay of FSaII tumors (s.c.) in the legs of C3H mice. Both metformin and ionizing radiation activated AMPK leading to inactivation of mTOR and suppression of its downstream effectors such as S6K1 and 4EBP1, a crucial signaling pathway for proliferation and survival of cancer cells, in vitro as well as in the in vivo tumors. Conclusion: Metformin kills and radiosensitizes cancer cells and eradicates radioresistant cancer stem cells by activating AMPK and suppressing mTOR." @default.
- W2013687768 created "2016-06-24" @default.
- W2013687768 creator A5007185710 @default.
- W2013687768 creator A5025995653 @default.
- W2013687768 creator A5026713386 @default.
- W2013687768 creator A5051319218 @default.
- W2013687768 creator A5051714527 @default.
- W2013687768 creator A5068704956 @default.
- W2013687768 creator A5074403685 @default.
- W2013687768 creator A5074724834 @default.
- W2013687768 date "2012-04-12" @default.
- W2013687768 modified "2023-09-22" @default.
- W2013687768 title "Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells" @default.
- W2013687768 cites W1552614585 @default.
- W2013687768 cites W1980429197 @default.
- W2013687768 cites W1983225269 @default.
- W2013687768 cites W1990063646 @default.
- W2013687768 cites W1997203401 @default.
- W2013687768 cites W1998771362 @default.
- W2013687768 cites W2005912218 @default.
- W2013687768 cites W2009542601 @default.
- W2013687768 cites W2023316892 @default.
- W2013687768 cites W2023427658 @default.
- W2013687768 cites W2026967508 @default.
- W2013687768 cites W2028298372 @default.
- W2013687768 cites W2034145807 @default.
- W2013687768 cites W2042008937 @default.
- W2013687768 cites W2046272686 @default.
- W2013687768 cites W2048994966 @default.
- W2013687768 cites W2056889415 @default.
- W2013687768 cites W2057139536 @default.
- W2013687768 cites W2060551076 @default.
- W2013687768 cites W2064176617 @default.
- W2013687768 cites W2064656431 @default.
- W2013687768 cites W2078190084 @default.
- W2013687768 cites W2083479805 @default.
- W2013687768 cites W2084513141 @default.
- W2013687768 cites W2093216555 @default.
- W2013687768 cites W2097308038 @default.
- W2013687768 cites W2098400442 @default.
- W2013687768 cites W2100358697 @default.
- W2013687768 cites W2101399403 @default.
- W2013687768 cites W2108035852 @default.
- W2013687768 cites W2108183713 @default.
- W2013687768 cites W2115325946 @default.
- W2013687768 cites W2123014930 @default.
- W2013687768 cites W2125292576 @default.
- W2013687768 cites W2125747634 @default.
- W2013687768 cites W2127107445 @default.
- W2013687768 cites W2129433069 @default.
- W2013687768 cites W2129567747 @default.
- W2013687768 cites W2130926378 @default.
- W2013687768 cites W2134987819 @default.
- W2013687768 cites W2135492658 @default.
- W2013687768 cites W2141018935 @default.
- W2013687768 cites W2145566175 @default.
- W2013687768 cites W2147495392 @default.
- W2013687768 cites W2147589302 @default.
- W2013687768 cites W2147631083 @default.
- W2013687768 cites W2153980878 @default.
- W2013687768 cites W2157000986 @default.
- W2013687768 cites W2163292580 @default.
- W2013687768 cites W2166583179 @default.
- W2013687768 cites W2171998898 @default.
- W2013687768 cites W2241369966 @default.
- W2013687768 doi "https://doi.org/10.1038/srep00362" @default.
- W2013687768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3324825" @default.
- W2013687768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22500211" @default.
- W2013687768 hasPublicationYear "2012" @default.
- W2013687768 type Work @default.
- W2013687768 sameAs 2013687768 @default.
- W2013687768 citedByCount "237" @default.
- W2013687768 countsByYear W20136877682012 @default.
- W2013687768 countsByYear W20136877682013 @default.
- W2013687768 countsByYear W20136877682014 @default.
- W2013687768 countsByYear W20136877682015 @default.
- W2013687768 countsByYear W20136877682016 @default.
- W2013687768 countsByYear W20136877682017 @default.
- W2013687768 countsByYear W20136877682018 @default.
- W2013687768 countsByYear W20136877682019 @default.
- W2013687768 countsByYear W20136877682020 @default.
- W2013687768 countsByYear W20136877682021 @default.
- W2013687768 countsByYear W20136877682022 @default.
- W2013687768 countsByYear W20136877682023 @default.
- W2013687768 crossrefType "journal-article" @default.
- W2013687768 hasAuthorship W2013687768A5007185710 @default.
- W2013687768 hasAuthorship W2013687768A5025995653 @default.
- W2013687768 hasAuthorship W2013687768A5026713386 @default.
- W2013687768 hasAuthorship W2013687768A5051319218 @default.
- W2013687768 hasAuthorship W2013687768A5051714527 @default.
- W2013687768 hasAuthorship W2013687768A5068704956 @default.
- W2013687768 hasAuthorship W2013687768A5074403685 @default.
- W2013687768 hasAuthorship W2013687768A5074724834 @default.
- W2013687768 hasBestOaLocation W20136877681 @default.
- W2013687768 hasConcept C117262875 @default.
- W2013687768 hasConcept C121608353 @default.
- W2013687768 hasConcept C126322002 @default.
- W2013687768 hasConcept C154317977 @default.
- W2013687768 hasConcept C202751555 @default.
- W2013687768 hasConcept C206684579 @default.