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- W2013694927 abstract "Flumethiazide [6-(trifluoromethyl)-1,4,2-benzothiadiazine-7-sulfonamide,1 ,l -dioxide] differs structurally from chlorothiazide in the presence of the tri-fluro group in place of the chloride. We have used previously described technics for the bioassay of diuretic potency, electrolyte excretion effects, serum biochemical changes, repetitive effectiveness and antihypertensive potency. The antihypertensive effects were observed in twenty-five outpatients while all other studies were carried out under controlled metabolic conditions. Flumethiazide administered in doses of 1.0 and 2.0 gm., orally, is 0.7 times as potent as meralluride (Mercuhydrin@), intramuscularly, as a natriuretic agent. (Diuril is 0.8 times as potent.) However, there is an increase in sodium excretion at doses as low as 250 mg. The effects on electrolyte excretion are similar to those observed after the administration of chlorothiazide (primarily changes in sodium and chloride, with small changes in potassium and bicarbonate). The drug is repetitively effective on continuous daily use and produces minor disturbances in serum biochemical architecture similar to that of chlorothiazide. There is no significant difference in its antihypertensive potency from that of chlorothiazide. Flumethiazide appears to be another valuable agent in the management of edema and hypertension." @default.
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- W2013694927 date "1959-08-01" @default.
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- W2013694927 title "Staphylococcal bacteremia in dogs: Effect of uremia, splenectomy, and splenectomy plus portacaval shunt on the rates of clearance from the blood stream" @default.
- W2013694927 doi "https://doi.org/10.1016/0002-9343(59)90368-7" @default.
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