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- W2013702362 abstract "1. 1. In this study, we investigated the effects of chronic Auro-detoxin treatment for 5 and 10 weeks on reactivity to vascular agonists in the mouse aorta. 2. 2. The maximum contractile responses to and the -log EC 50 values of phenylephrine (Phe) were not changed with Auro-detoxin treatment. 3. 3. The maximum contractile responses to 5-hydroxytryptamine (5-HT) were not changed over 5 weeks but were significantly increased with Auro-detoxin treatment during a 10-week period. The -log EC 50 values of 5-HT were found to be significantly decreased in both treatment groups. 4. 4. The maximum relaxation responses to acetylcholine (ACh) were decreased in both treatment groups. The -log EC 50 values of ACh were not changed in 5 weeks but significantly decreased in 10-week-treated animals. 5. 5. Neither the maximum relaxation responses nor the -log EC 50 values of sodium nitroprusside (SNP) were changed with Auro-detoxin treatment. 6. 6. These results suggest that chronic gold treatment affects vascular responses in the mouse aorta." @default.
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- W2013702362 title "Effects of auro-detoxin treatment on vascular responses in mouse aorta" @default.
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- W2013702362 doi "https://doi.org/10.1016/s0306-3623(96)00354-0" @default.
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