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W2013702972 abstract "Monocyte infiltration is implicated in a variety of diseases including multiple myeloma, rheumatoid arthritis, and multiple sclerosis. C−C chemokine receptor 1 (CCR1) is a chemokine receptor that upon stimulation, particularly by macrophage inflammatory protein 1α (MIP-1α) and regulated on normal T-cell expressed and secreted (RANTES), mediates monocyte trafficking to sites of inflammation. High throughput screening of our combinatorial collection identified a novel, moderately potent CCR1 antagonist 3. The library hit 3 was optimized to the advanced lead compound 4. Compound 4 inhibited CCR1 mediated chemotaxis of monocytes with an IC50 of 20 nM. In addition, the compound was highly selective over other chemokine receptors. It had good microsomal stability when incubated with rat and human liver microsomes and showed no significant cytochrome P450 (CYP) inhibition. Pharmacokinetic evaluation of the compound in the rat showed good oral bioavailability." @default.
W2013702972 created "2016-06-24" @default.
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W2013702972 date "2009-01-30" @default.
W2013702972 modified "2023-10-16" @default.
W2013702972 title "Novel Pyrrolidine Ureas as C−C Chemokine Receptor 1 (CCR1) Antagonists" @default.
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W2013702972 doi "https://doi.org/10.1021/jm801416q" @default.
W2013702972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19183043" @default.
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