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- W2013703025 abstract "A phase 1, dose-escalating trial was conducted in healthy adults to evaluate immunogenicity and reactogenicity of a type V group B streptococcal (GBS) capsular polysaccharide (CPS)–tetanus toxoid (TT) conjugate vaccine. Participants received one dose of unconjugated V CPS (37 μg), V–TT (2.4 μg CPS/1.1 μg TT), V–TT (9.6 μg CPS/4.3 μg TT) or V–TT (38.5 μg CPS/17.0 μg TT). Each vaccine and all doses of V–TT were well-tolerated. V CPS-specific antibodies reached a peak 4–8 weeks after immunization and were significantly higher through 52 weeks post-immunization in recipients of V–TT at each dose than in uncoupled CPS vaccinees. V–TT vaccine-induced antibodies promoted opsonophagocytic killing of type V GBS and avidity maturation of V CPS-specific IgG." @default.
- W2013703025 created "2016-06-24" @default.
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- W2013703025 date "2007-01-01" @default.
- W2013703025 modified "2023-09-27" @default.
- W2013703025 title "Dose–response to type V group B streptococcal polysaccharide–tetanus toxoid conjugate vaccine in healthy adults" @default.
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- W2013703025 doi "https://doi.org/10.1016/j.vaccine.2006.07.018" @default.
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