Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013703648> ?p ?o ?g. }
- W2013703648 endingPage "17057" @default.
- W2013703648 startingPage "17052" @default.
- W2013703648 abstract "A growing body of literature has examined and implicated DNA methylation as a critical epigenetic modification in T helper (Th) cell differentiation. The absence of DNA methyltransferases or methyl-binding proteins derepresses many cytokine loci, allowing their ectopic expression, while methylation of specific CpG residues is sufficient to prevent expression. Here, we characterize demethylation events of the Th2 cytokine locus control region (LCR). rad50 hypersensitive site 7 (RHS7), a hypersensitive site within this LCR, becomes demethylated in a STAT6-dependent manner and only in cells stimulated under type 2 conditions. Robust demethylation appears to require signaling contributions from both IL-4 receptor, via STAT6, and CD28, but it cannot be effected by GATA3. Finally, RHS7 is demethylated independently of cell division, consistent with an active, rather than passive, mechanism. Taken together, these findings firmly connect RHS7 demethylation and Th2 LCR activation in the type 2 differentiation program." @default.
- W2013703648 created "2016-06-24" @default.
- W2013703648 creator A5015421326 @default.
- W2013703648 creator A5064443404 @default.
- W2013703648 creator A5082776591 @default.
- W2013703648 date "2007-10-23" @default.
- W2013703648 modified "2023-10-15" @default.
- W2013703648 title "Demethylation of a specific hypersensitive site in the Th2 locus control region" @default.
- W2013703648 cites W1483688385 @default.
- W2013703648 cites W1507518053 @default.
- W2013703648 cites W1578776025 @default.
- W2013703648 cites W1963341208 @default.
- W2013703648 cites W1967064280 @default.
- W2013703648 cites W1967261754 @default.
- W2013703648 cites W1973727308 @default.
- W2013703648 cites W1979657237 @default.
- W2013703648 cites W1985364817 @default.
- W2013703648 cites W1988290255 @default.
- W2013703648 cites W1993068868 @default.
- W2013703648 cites W1993426597 @default.
- W2013703648 cites W2008958781 @default.
- W2013703648 cites W2011405307 @default.
- W2013703648 cites W2020096790 @default.
- W2013703648 cites W2020775355 @default.
- W2013703648 cites W2022447132 @default.
- W2013703648 cites W2023488690 @default.
- W2013703648 cites W2026082697 @default.
- W2013703648 cites W2032917789 @default.
- W2013703648 cites W2067500883 @default.
- W2013703648 cites W2070491119 @default.
- W2013703648 cites W2073157961 @default.
- W2013703648 cites W2074140050 @default.
- W2013703648 cites W2078028724 @default.
- W2013703648 cites W2083103029 @default.
- W2013703648 cites W2086368962 @default.
- W2013703648 cites W2089253191 @default.
- W2013703648 cites W2095294902 @default.
- W2013703648 cites W2099845842 @default.
- W2013703648 cites W2102450081 @default.
- W2013703648 cites W2121417064 @default.
- W2013703648 cites W2122534935 @default.
- W2013703648 cites W2122545452 @default.
- W2013703648 cites W2135041525 @default.
- W2013703648 cites W2136278733 @default.
- W2013703648 cites W2146163075 @default.
- W2013703648 cites W2151627258 @default.
- W2013703648 cites W2152978188 @default.
- W2013703648 cites W2156825952 @default.
- W2013703648 cites W2161227229 @default.
- W2013703648 doi "https://doi.org/10.1073/pnas.0708293104" @default.
- W2013703648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2040439" @default.
- W2013703648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17940027" @default.
- W2013703648 hasPublicationYear "2007" @default.
- W2013703648 type Work @default.
- W2013703648 sameAs 2013703648 @default.
- W2013703648 citedByCount "59" @default.
- W2013703648 countsByYear W20137036482012 @default.
- W2013703648 countsByYear W20137036482013 @default.
- W2013703648 countsByYear W20137036482014 @default.
- W2013703648 countsByYear W20137036482015 @default.
- W2013703648 countsByYear W20137036482016 @default.
- W2013703648 countsByYear W20137036482017 @default.
- W2013703648 countsByYear W20137036482018 @default.
- W2013703648 countsByYear W20137036482019 @default.
- W2013703648 countsByYear W20137036482020 @default.
- W2013703648 countsByYear W20137036482023 @default.
- W2013703648 crossrefType "journal-article" @default.
- W2013703648 hasAuthorship W2013703648A5015421326 @default.
- W2013703648 hasAuthorship W2013703648A5064443404 @default.
- W2013703648 hasAuthorship W2013703648A5082776591 @default.
- W2013703648 hasBestOaLocation W20137036481 @default.
- W2013703648 hasConcept C101762097 @default.
- W2013703648 hasConcept C104317684 @default.
- W2013703648 hasConcept C140173407 @default.
- W2013703648 hasConcept C150194340 @default.
- W2013703648 hasConcept C158448853 @default.
- W2013703648 hasConcept C16824249 @default.
- W2013703648 hasConcept C190727270 @default.
- W2013703648 hasConcept C202199734 @default.
- W2013703648 hasConcept C33288867 @default.
- W2013703648 hasConcept C41091548 @default.
- W2013703648 hasConcept C54355233 @default.
- W2013703648 hasConcept C552990157 @default.
- W2013703648 hasConcept C58237431 @default.
- W2013703648 hasConcept C86339819 @default.
- W2013703648 hasConcept C86803240 @default.
- W2013703648 hasConcept C91965660 @default.
- W2013703648 hasConcept C95444343 @default.
- W2013703648 hasConcept C97037327 @default.
- W2013703648 hasConceptScore W2013703648C101762097 @default.
- W2013703648 hasConceptScore W2013703648C104317684 @default.
- W2013703648 hasConceptScore W2013703648C140173407 @default.
- W2013703648 hasConceptScore W2013703648C150194340 @default.
- W2013703648 hasConceptScore W2013703648C158448853 @default.
- W2013703648 hasConceptScore W2013703648C16824249 @default.
- W2013703648 hasConceptScore W2013703648C190727270 @default.
- W2013703648 hasConceptScore W2013703648C202199734 @default.
- W2013703648 hasConceptScore W2013703648C33288867 @default.