FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013703886> ?p ?o ?g. }

• W2013703886 endingPage "3407" @default.
• W2013703886 startingPage "3407" @default.
• W2013703886 abstract "To identify methylation profile and novel tumor marker of extrahepatic cholangiocarcinoma (CCA) with high throughout microarray.Differential methylation profile was compared between normal bile duct epithelial cell lines and CCA cell lines by methyl-DNA immunoprecipitation (MeDIP) microarray. Bisulfite-polymerase chain reaction (BSP) was performed to identify the methylated allels of target genes. Expression of target genes was investigated before and after the treatment with DNA demethylating agent. Expression of candidate genes was also evaluated by immunofluorescence in 30 specimens of CCA tissues and 9 normal bile duct tissues.Methylation profile of CCA was identified with MeDIP microarray in the respects of different gene functions and signaling pathways. Interestingly, 97 genes with hypermethylated CpG islands in the promoter region were homeobox genes. The top 5 hypermethylated homeobox genes validated by BSP were HOXA2 (94.29%), HOXA5 (95.38%), HOXA11 (91.67%), HOXB4 (90.56%) and HOXD13 (94.38%). Expression of these genes was reactivated with 5'-aza-2'-deoxycytidine. Significant expression differences were found between normal bile duct and extrahepatic CCA tissues (66.67%-100% vs 3.33%-10%).HOXA2, HOXA5, HOXA11, HOXB4 and HOXD13 may work as differential epigenetic biomarkers between malignant and benign biliary tissues." @default.
• W2013703886 created "2016-06-24" @default.
• W2013703886 creator A5007763763 @default.
• W2013703886 creator A5028299729 @default.
• W2013703886 creator A5040040696 @default.
• W2013703886 creator A5043091074 @default.
• W2013703886 creator A5052713292 @default.
• W2013703886 date "2011-01-01" @default.
• W2013703886 modified "2023-10-16" @default.
• W2013703886 title "Identification of methylation profile of HOX genes in extrahepatic cholangiocarcinoma" @default.
• W2013703886 cites W1582030261 @default.
• W2013703886 cites W1967841068 @default.
• W2013703886 cites W1974654024 @default.
• W2013703886 cites W1975364471 @default.
• W2013703886 cites W1978756198 @default.
• W2013703886 cites W1984195396 @default.
• W2013703886 cites W2009193187 @default.
• W2013703886 cites W2014744205 @default.
• W2013703886 cites W2019769511 @default.
• W2013703886 cites W2020396992 @default.
• W2013703886 cites W2020634229 @default.
• W2013703886 cites W2023795717 @default.
• W2013703886 cites W2026843427 @default.
• W2013703886 cites W2035122273 @default.
• W2013703886 cites W2039704444 @default.
• W2013703886 cites W2046509449 @default.
• W2013703886 cites W2050880607 @default.
• W2013703886 cites W2056369065 @default.
• W2013703886 cites W2061611574 @default.
• W2013703886 cites W2065751798 @default.
• W2013703886 cites W2065949767 @default.
• W2013703886 cites W2066171378 @default.
• W2013703886 cites W2067424864 @default.
• W2013703886 cites W2075399812 @default.
• W2013703886 cites W2075704079 @default.
• W2013703886 cites W2082959814 @default.
• W2013703886 cites W2084102070 @default.
• W2013703886 cites W2095452565 @default.
• W2013703886 cites W2096149908 @default.
• W2013703886 cites W2097934124 @default.
• W2013703886 cites W2100484141 @default.
• W2013703886 cites W2110209907 @default.
• W2013703886 cites W2117802160 @default.
• W2013703886 cites W2123174009 @default.
• W2013703886 cites W2141410747 @default.
• W2013703886 cites W2146344535 @default.
• W2013703886 cites W2146556279 @default.
• W2013703886 cites W2146884931 @default.
• W2013703886 cites W2164627030 @default.
• W2013703886 cites W2164847390 @default.
• W2013703886 cites W3026147203 @default.
• W2013703886 doi "https://doi.org/10.3748/wjg.v17.i29.3407" @default.
• W2013703886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3160567" @default.
• W2013703886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21876633" @default.
• W2013703886 hasPublicationYear "2011" @default.
• W2013703886 type Work @default.
• W2013703886 sameAs 2013703886 @default.
• W2013703886 citedByCount "24" @default.
• W2013703886 countsByYear W20137038862012 @default.
• W2013703886 countsByYear W20137038862013 @default.
• W2013703886 countsByYear W20137038862014 @default.
• W2013703886 countsByYear W20137038862015 @default.
• W2013703886 countsByYear W20137038862016 @default.
• W2013703886 countsByYear W20137038862018 @default.
• W2013703886 countsByYear W20137038862019 @default.
• W2013703886 countsByYear W20137038862020 @default.
• W2013703886 countsByYear W20137038862021 @default.
• W2013703886 countsByYear W20137038862022 @default.
• W2013703886 countsByYear W20137038862023 @default.
• W2013703886 crossrefType "journal-article" @default.
• W2013703886 hasAuthorship W2013703886A5007763763 @default.
• W2013703886 hasAuthorship W2013703886A5028299729 @default.
• W2013703886 hasAuthorship W2013703886A5040040696 @default.
• W2013703886 hasAuthorship W2013703886A5043091074 @default.
• W2013703886 hasAuthorship W2013703886A5052713292 @default.
• W2013703886 hasBestOaLocation W20137038861 @default.
• W2013703886 hasConcept C104317684 @default.
• W2013703886 hasConcept C111039654 @default.
• W2013703886 hasConcept C116114238 @default.
• W2013703886 hasConcept C121587040 @default.
• W2013703886 hasConcept C150194340 @default.
• W2013703886 hasConcept C153911025 @default.
• W2013703886 hasConcept C189235521 @default.
• W2013703886 hasConcept C190727270 @default.
• W2013703886 hasConcept C2779277951 @default.
• W2013703886 hasConcept C33288867 @default.
• W2013703886 hasConcept C41091548 @default.
• W2013703886 hasConcept C502942594 @default.
• W2013703886 hasConcept C54355233 @default.
• W2013703886 hasConcept C8415881 @default.
• W2013703886 hasConcept C86803240 @default.
• W2013703886 hasConceptScore W2013703886C104317684 @default.
• W2013703886 hasConceptScore W2013703886C111039654 @default.
• W2013703886 hasConceptScore W2013703886C116114238 @default.
• W2013703886 hasConceptScore W2013703886C121587040 @default.
• W2013703886 hasConceptScore W2013703886C150194340 @default.
• W2013703886 hasConceptScore W2013703886C153911025 @default.
• W2013703886 hasConceptScore W2013703886C189235521 @default.

• next