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• W2013706075 endingPage "90" @default.
• W2013706075 startingPage "70" @default.
• W2013706075 abstract "The aim of this review is to describe the level of intimacy between Ty retrotransposons (Ty1-Ty5) and their host the yeast Saccharomyces cerevisiae. The effects of Ty location in the genome and of host proteins on the expression and mobility of Ty elements are highlighted. After a brief overview of Ty diversity and evolution, we describe the factors that dictate Ty target-site preference and the impact of targeting on Ty and adjacent gene expression. Studies on Ty3 and Ty5 have been especially informative in unraveling the role of host factors (Pol III machinery and silencing proteins, respectively) and integrase in controlling the specificity of integration. In contrast, not much is known regarding Ty1, Ty2 and Ty4, except that their insertion depends on the transcriptional competence of the adjacent Pol III gene and might be influenced by some chromatin components. This review also brings together recent findings on the regulation of Ty1 retrotransposition. A large number of host proteins (over 30) involved in a wide range of cellular processes controls either directly or indirectly Ty1 mobility, primarily at post-transcriptional steps. We focus on several genes for which more detailed analyses have permitted the elaboration of regulatory models. In addition, this review describes new data revealing that repression of Ty1 mobility also involves two forms of copy number control that act at both the trancriptional and post-transcriptional levels. Since S. cerevisiae lacks the conserved pathways for copy number control via transcriptional and post-transcriptional gene silencing found in other eukaryotes, Ty1 copy number control must be via another mechanism whose features are outlined. Ty1 response to stress also implicates activation at both transcriptional and postranscriptional steps of Ty1. Finally, we provide several insights in the role of Ty elements in chromosome evolution and yeast adaptation and discuss the factors that might limit Ty ectopic recombination." @default.
• W2013706075 created "2016-06-24" @default.
• W2013706075 creator A5052972676 @default.
• W2013706075 creator A5071238226 @default.
• W2013706075 date "2005-01-01" @default.
• W2013706075 modified "2023-10-18" @default.
• W2013706075 title "Happy together: the life and times of Ty retrotransposons and their hosts" @default.
• W2013706075 cites W110705602 @default.
• W2013706075 cites W144560379 @default.
• W2013706075 cites W1489318723 @default.
• W2013706075 cites W1531173479 @default.
• W2013706075 cites W1555887143 @default.
• W2013706075 cites W1567722565 @default.
• W2013706075 cites W1569028548 @default.
• W2013706075 cites W1603634953 @default.
• W2013706075 cites W1643938048 @default.
• W2013706075 cites W1775348910 @default.
• W2013706075 cites W1784860041 @default.
• W2013706075 cites W1809615063 @default.
• W2013706075 cites W1821994922 @default.
• W2013706075 cites W1833145860 @default.
• W2013706075 cites W1858119869 @default.
• W2013706075 cites W1886610814 @default.
• W2013706075 cites W1906249372 @default.
• W2013706075 cites W1911887027 @default.
• W2013706075 cites W1915393084 @default.
• W2013706075 cites W1925064470 @default.
• W2013706075 cites W1940661423 @default.
• W2013706075 cites W1953861638 @default.
• W2013706075 cites W1963996414 @default.
• W2013706075 cites W1966695495 @default.
• W2013706075 cites W1966903120 @default.
• W2013706075 cites W1966985571 @default.
• W2013706075 cites W1971217614 @default.
• W2013706075 cites W1972068359 @default.
• W2013706075 cites W1972852906 @default.
• W2013706075 cites W1974726647 @default.
• W2013706075 cites W1977188840 @default.
• W2013706075 cites W1977871027 @default.
• W2013706075 cites W1978323800 @default.
• W2013706075 cites W1979015046 @default.
• W2013706075 cites W1981531064 @default.
• W2013706075 cites W1981866732 @default.
• W2013706075 cites W1982616275 @default.
• W2013706075 cites W1983426450 @default.
• W2013706075 cites W1984158753 @default.
• W2013706075 cites W1989092936 @default.
• W2013706075 cites W1993088593 @default.
• W2013706075 cites W1993623149 @default.
• W2013706075 cites W1993854560 @default.
• W2013706075 cites W1993858584 @default.
• W2013706075 cites W1995090181 @default.
• W2013706075 cites W1996684631 @default.
• W2013706075 cites W1999227561 @default.
• W2013706075 cites W1999813420 @default.
• W2013706075 cites W2001372713 @default.
• W2013706075 cites W2006132678 @default.
• W2013706075 cites W2006873092 @default.
• W2013706075 cites W2008404592 @default.
• W2013706075 cites W2011221649 @default.
• W2013706075 cites W2011894292 @default.
• W2013706075 cites W2014049724 @default.
• W2013706075 cites W2022113867 @default.
• W2013706075 cites W2022936129 @default.
• W2013706075 cites W2024675966 @default.
• W2013706075 cites W2025579261 @default.
• W2013706075 cites W2026380926 @default.
• W2013706075 cites W2029957242 @default.
• W2013706075 cites W2030256602 @default.
• W2013706075 cites W2033676950 @default.
• W2013706075 cites W2034252391 @default.
• W2013706075 cites W2034856837 @default.
• W2013706075 cites W2035160015 @default.
• W2013706075 cites W2035523285 @default.
• W2013706075 cites W2036479240 @default.
• W2013706075 cites W2037320704 @default.
• W2013706075 cites W2039940539 @default.
• W2013706075 cites W2041880715 @default.
• W2013706075 cites W2042960789 @default.
• W2013706075 cites W2044042298 @default.
• W2013706075 cites W2044543540 @default.
• W2013706075 cites W2045248726 @default.
• W2013706075 cites W2045399169 @default.
• W2013706075 cites W2045862142 @default.
• W2013706075 cites W2046934016 @default.
• W2013706075 cites W2047395555 @default.
• W2013706075 cites W2048566201 @default.
• W2013706075 cites W2050074995 @default.
• W2013706075 cites W2050194148 @default.
• W2013706075 cites W2056193644 @default.
• W2013706075 cites W2056480485 @default.
• W2013706075 cites W2059718902 @default.
• W2013706075 cites W2060742513 @default.
• W2013706075 cites W2060936931 @default.
• W2013706075 cites W2062119499 @default.
• W2013706075 cites W2062548426 @default.
• W2013706075 cites W2064282309 @default.
• W2013706075 cites W2066955442 @default.

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