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- W2013706592 abstract "Purpose: The ability of a tumor to grow requires the recruitment of new vasculature. Recent studies have demonstrated the antiangiogenic effect of soluble receptors to VEGF. Our goal was to evaluate the effects, against fibrosacrcoma T241, of radiotherapy and an adeno viral construct of the soluble Flk receptor conjugated to mouse-Fc in vivo. Methods: The right thighs of sixty C57 black mice were injected subcutaneously with 1X106 T241 cells. When the tumors reached 750 mm3 the animals were randomized to one of six groups: no treatment, radiotherapy alone, AdFc alone, AdFlk1-Fc alone, AdFc plus radiotherapy and AdFlk1-Fc plus radiotherapy. The radiotherapy was given in 6 Gy fractions for five fractions using a Cesium source. Radiation was initiated nine days post-implantation. Tumor volume was measured every three days and volumes calculated by L∗W2/0.52. Growth delay was calculated as the time to reach 2000mm3 compared to controls. The median and standard deviations for each group were calculated. Results: Overall the treated mice had little toxicity from the treatment as measured by continued weight gain. With the T241 tumors injected with PBS as controls we saw a growth delay of 0 days for AdFc alone, 12 days for radiotherapy alone, 7 days for AdFlk1-Fc alone, 10.5 days for AdFc and radiotherapy and 30.5 days for AdFlk1-Fc and radiotherapy. The effect of the combination of the AdFlk-1-Fc and radiotherapy was greater then either therapy alone. The results were statistically significant with p=0.00001. Conclusions: The combined treatment with AdFlk1-Fc and radiotherapy demonstrates a greater then additive effect against primary murine tumors in vivo. There appears to be little acute increased toxicity of this combination treatment." @default.
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- W2013706592 date "2001-11-01" @default.
- W2013706592 modified "2023-09-27" @default.
- W2013706592 title "Radiation therapy plus ADFlk1-Fc has a synergistic effect against fibrosarcoma T241 in mice" @default.
- W2013706592 doi "https://doi.org/10.1016/s0360-3016(01)02107-1" @default.
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