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• W2013707087 endingPage "3364" @default.
• W2013707087 startingPage "3356" @default.
• W2013707087 abstract "The competitive adsorption of fibrinogen and high molecular weight kininogen at different flow rates on silica capillaries has been studied at 37 °C in Tris buffer (Tris 0.05 M; NaCl 0.10 M) and at a dilution of 10-2 with respect to the plasma concentrations. By radiolabeling (125I and 131I) each protein differently, it is possible to follow the adsorption of both molecules from the mixture simultaneously. An accumulation of both proteins at the interface followed by a progressive release of fibrinogen was observed. This release was not necessarily associated with an increase of the kininogen interfacial concentration. From an analysis of the initial kinetics of adsorption of kininogen vs wall shear rate, the diffusion coefficient (D ≈ 4.4 × 10-7 cm2 s-1) and the adsorption constant (ka ≈ 2.4 × 10-4 cm s-1) have been derived. The final adsorption kinetics of kininogen in the presence of fibrinogen is more compatible with a site adsorption model than with a random sequential adsorption model and leads to a much smaller adsorption constant, of the order of 10-5 cm s-1. This suggests that kininogen does not interact directly with the bare silica but with fibrinogen molecules, which act as adsorption sites. For the molecular ratio of proteins in solution used here, it was found that the interfacial concentrations of both proteins are independent of shear rates at the maximum of fibrinogen concentration (0.4 μg cm-2 for fibrinogen (Fib) and 0.1 μg cm-2 for kininogen (HK)), although appearing at varying times. These concentrations correspond to a molecular ratio HK/Fib of 0.9, which is close to an equimolecular composition at the interface. However at the beginning of the adsorption process, we measured one molecule of kininogen for 10 molecules of fibrinogen at the surface, in accordance with a theoretical estimation from the solution concentrations and molecular masses." @default.
• W2013707087 created "2016-06-24" @default.
• W2013707087 creator A5041201239 @default.
• W2013707087 creator A5059663653 @default.
• W2013707087 date "1998-05-23" @default.
• W2013707087 modified "2023-10-10" @default.
• W2013707087 title "Simultaneous Adsorption of Fibrinogen and Kininogen at a Silica/Solution Interface" @default.
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• W2013707087 doi "https://doi.org/10.1021/la9713513" @default.
• W2013707087 hasPublicationYear "1998" @default.
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