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- W2013709166 abstract "This review considers the problem of osteoporosis in the context of present knowledge (and its limitations) of the mechanisms of bone resorption and bone formation. Two particular points are emphasized: (1) osteoporosis is a disorder characterized by an imbalance between formation and resorption in favor of the latter; and (2) both bone formation and resorption are regulated by the local ionic environment as well as the activities of several hormones. A rational therapy for this condition will undoubtedly have to take account of both processes and of means of enhancing the one (formation) and suppressing the other (resorption). In the latter context, thyrocalcitonin has already been shown to have a profound effect in experimental animals, but one disturbing feature of its action is the very striking decrease in its effectiveness in older animals. Whether or not this will be a major limitation to its use in adult human subjects remains to be established. The final portion of this review considers the recent evidence that thyrocalcitonin and parathyroid hormone control metabolism by regulating the fluxes of calcium and magnesium across cellular and subcellular membranes as well as the activities of enzymes whose functions are controlled by these cations. Specific attention is directed to the effects of these hormones upon the activity of pyrophosphatase, an enzyme specifically implicated in bone metabolism." @default.
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- W2013709166 date "1967-11-01" @default.
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- W2013709166 title "Thyrocalcitonin, osteoporosis and osteolysis" @default.
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- W2013709166 doi "https://doi.org/10.1016/0002-9343(67)90113-1" @default.
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