FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013724055> ?p ?o ?g. }

• W2013724055 endingPage "6600" @default.
• W2013724055 startingPage "6596" @default.
• W2013724055 abstract "A key role has not yet been identified for beta nerve growth factor (NGF) in the growth responses that continue to be expressed in the sensory neurons of adult animals. We have now examined the effects of daily administration to adult rats (and in a few experiments, mice) of antiserum to NGF on (i) the collateral sprouting of undamaged nociceptive nerves that occurs into denervated adjacent skin and (ii) the regeneration of cutaneous sensory axons that occurs after they are damaged. The results were unexpected. All collateral sprouting was prevented and that already in progress was halted; sprouting resumed when treatment was discontinued. In contrast, the reestablishment, and even enlargement, of cutaneous nerve fields by regenerating axons was unaffected by anti-NGF treatment, even after dorsal rhizotomy was done to eliminate any central trophic support. In denervated skin, regenerating and collaterally sprouting axons utilized the same cellular pathways to establish functionally identical fields, thus displaying apparently identical growth behaviors, yet anti-NGF treatment clearly distinguished between them. We suggest that endogenous NGF is responsible for the collateral sprouting of nociceptive axons, probably reflecting an ongoing function of NGF in the regulation of their fields. This demonstration in the adult sensory system of a defined role for NGF in nerve growth could apply to nerve growth factors generally in the adult nervous system. The regeneration, however, of nociceptive axons (and nonnociceptive one) is not dependent on NGF." @default.
• W2013724055 created "2016-06-24" @default.
• W2013724055 creator A5017207534 @default.
• W2013724055 creator A5045710219 @default.
• W2013724055 creator A5063642369 @default.
• W2013724055 creator A5073172437 @default.
• W2013724055 creator A5090368266 @default.
• W2013724055 date "1987-09-01" @default.
• W2013724055 modified "2023-10-14" @default.
• W2013724055 title "Evidence that endogenous beta nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats." @default.
• W2013724055 cites W1565785673 @default.
• W2013724055 cites W1581555583 @default.
• W2013724055 cites W1779079410 @default.
• W2013724055 cites W1897632924 @default.
• W2013724055 cites W1917144620 @default.
• W2013724055 cites W1943349188 @default.
• W2013724055 cites W1968860081 @default.
• W2013724055 cites W1968962148 @default.
• W2013724055 cites W1972729557 @default.
• W2013724055 cites W1977209656 @default.
• W2013724055 cites W1981238039 @default.
• W2013724055 cites W1982480548 @default.
• W2013724055 cites W1987932065 @default.
• W2013724055 cites W1992623778 @default.
• W2013724055 cites W1998660108 @default.
• W2013724055 cites W2000845719 @default.
• W2013724055 cites W2003378719 @default.
• W2013724055 cites W2004179558 @default.
• W2013724055 cites W2004490869 @default.
• W2013724055 cites W2014731769 @default.
• W2013724055 cites W2015538597 @default.
• W2013724055 cites W2015628975 @default.
• W2013724055 cites W2016131735 @default.
• W2013724055 cites W2017681525 @default.
• W2013724055 cites W2021302041 @default.
• W2013724055 cites W2023664289 @default.
• W2013724055 cites W2035385675 @default.
• W2013724055 cites W2036169022 @default.
• W2013724055 cites W2040853724 @default.
• W2013724055 cites W2046635169 @default.
• W2013724055 cites W2051121048 @default.
• W2013724055 cites W2059119251 @default.
• W2013724055 cites W2074155360 @default.
• W2013724055 cites W2076397220 @default.
• W2013724055 cites W2077928318 @default.
• W2013724055 cites W2083733985 @default.
• W2013724055 cites W2084141686 @default.
• W2013724055 cites W2086416639 @default.
• W2013724055 cites W2091560787 @default.
• W2013724055 cites W2117341843 @default.
• W2013724055 cites W2132254207 @default.
• W2013724055 cites W2133173415 @default.
• W2013724055 cites W2136731087 @default.
• W2013724055 cites W2137873308 @default.
• W2013724055 cites W2179733813 @default.
• W2013724055 cites W2256346215 @default.
• W2013724055 cites W2298970693 @default.
• W2013724055 cites W2396748657 @default.
• W2013724055 cites W2417885988 @default.
• W2013724055 cites W2473245970 @default.
• W2013724055 cites W3105898142 @default.
• W2013724055 doi "https://doi.org/10.1073/pnas.84.18.6596" @default.
• W2013724055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/299126" @default.
• W2013724055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3306683" @default.
• W2013724055 hasPublicationYear "1987" @default.
• W2013724055 type Work @default.
• W2013724055 sameAs 2013724055 @default.
• W2013724055 citedByCount "223" @default.
• W2013724055 countsByYear W20137240552012 @default.
• W2013724055 countsByYear W20137240552013 @default.
• W2013724055 countsByYear W20137240552014 @default.
• W2013724055 countsByYear W20137240552015 @default.
• W2013724055 countsByYear W20137240552016 @default.
• W2013724055 countsByYear W20137240552017 @default.
• W2013724055 countsByYear W20137240552018 @default.
• W2013724055 countsByYear W20137240552019 @default.
• W2013724055 countsByYear W20137240552020 @default.
• W2013724055 countsByYear W20137240552021 @default.
• W2013724055 countsByYear W20137240552022 @default.
• W2013724055 countsByYear W20137240552023 @default.
• W2013724055 crossrefType "journal-article" @default.
• W2013724055 hasAuthorship W2013724055A5017207534 @default.
• W2013724055 hasAuthorship W2013724055A5045710219 @default.
• W2013724055 hasAuthorship W2013724055A5063642369 @default.
• W2013724055 hasAuthorship W2013724055A5073172437 @default.
• W2013724055 hasAuthorship W2013724055A5090368266 @default.
• W2013724055 hasBestOaLocation W20137240551 @default.
• W2013724055 hasConcept C105702510 @default.
• W2013724055 hasConcept C134018914 @default.
• W2013724055 hasConcept C15490471 @default.
• W2013724055 hasConcept C16613235 @default.
• W2013724055 hasConcept C169760540 @default.
• W2013724055 hasConcept C170493617 @default.
• W2013724055 hasConcept C171056886 @default.
• W2013724055 hasConcept C2775908076 @default.
• W2013724055 hasConcept C2778241760 @default.
• W2013724055 hasConcept C2778423431 @default.
• W2013724055 hasConcept C2779530196 @default.

• next