FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013733462> ?p ?o ?g. }

• W2013733462 endingPage "53" @default.
• W2013733462 startingPage "44" @default.
• W2013733462 abstract "Sentinel lymph node evaluation is a critical component of melanoma staging, and lymph node status provides one of the most powerful predictors of melanoma recurrence and survival. One of the well-known diagnostic pitfalls in melanoma sentinel lymph node evaluation is the presence of nodal melanocytic nevi, which has been demonstrated in up to 26% of lymphadenectomy specimens and specifically in melanoma patients. Melanocytic markers enhance the sensitivity of melanoma detection in sentinel lymph nodes. However, established markers such as anti-melan-A/MART1, S100 protein and SOX10 antibodies cannot discriminate melanoma metastasis from nodal nevi. Recent studies have demonstrated strong expression of neural stem/progenitor cell markers nestin and SOX2 in melanoma. In this study, we tested the diagnostic utility of nestin and SOX2 in differentiating metastatic melanomas from nodal nevi. Twenty-three lymph nodes with metastatic melanomas and 17 with nodal nevi were examined. Of the 23 metastatic melanomas, 18 showed diffuse and strong (3+) nestin, 4 showed rare cells with strong (3+) nestin, and one showed diffuse but faint (1+) nestin staining. Nuclear SOX2 was positive in 13 metastatic melanomas. In contrast, 15 nodal nevi showed no nestin, and 2 showed rare cells with very faint (<1+) nestin staining. SOX2 was negative in 13 nodal nevi. Overall, nestin was strongly expressed in metastatic melanomas (n=22/23; 96%), but not in nodal melanocytic nevi (n=15/17; 88%; P<0.0001). SOX2 was also expressed in metastatic melanomas (n=13/23; 57%) but not in the majority of nodal melanocytic nevi (n=13/16; 81%; P=0.02). In one lymph node harboring metastatic melan-A-negative desmoplastic melanoma, nestin and SOX2 strongly highlighted the infiltrating tumor cells, suggesting the potential clinical value of these two markers in desmoplastic melanoma lymph node biopsies. This study provides evidence that nestin and SOX2 can effectively differentiate nodal melanocytic nevi from metastatic melanomas and serve as powerful diagnostic adjuncts in melanoma staging." @default.
• W2013733462 created "2016-06-24" @default.
• W2013733462 creator A5000872860 @default.
• W2013733462 creator A5032767831 @default.
• W2013733462 creator A5051862611 @default.
• W2013733462 creator A5081067188 @default.
• W2013733462 creator A5082234194 @default.
• W2013733462 date "2013-01-01" @default.
• W2013733462 modified "2023-09-28" @default.
• W2013733462 title "Diagnostic utility of neural stem and progenitor cell markers nestin and SOX2 in distinguishing nodal melanocytic nevi from metastatic melanomas" @default.
• W2013733462 cites W1559184507 @default.
• W2013733462 cites W1967656020 @default.
• W2013733462 cites W1970851105 @default.
• W2013733462 cites W1973144871 @default.
• W2013733462 cites W1987145582 @default.
• W2013733462 cites W1995475210 @default.
• W2013733462 cites W2000158882 @default.
• W2013733462 cites W2013302262 @default.
• W2013733462 cites W2013740436 @default.
• W2013733462 cites W2035592408 @default.
• W2013733462 cites W2041959121 @default.
• W2013733462 cites W2043746859 @default.
• W2013733462 cites W2055814692 @default.
• W2013733462 cites W2058304326 @default.
• W2013733462 cites W2093780223 @default.
• W2013733462 cites W2099374508 @default.
• W2013733462 cites W2112642558 @default.
• W2013733462 cites W2114611119 @default.
• W2013733462 cites W2121397969 @default.
• W2013733462 cites W2125987139 @default.
• W2013733462 cites W2143655292 @default.
• W2013733462 cites W2146043763 @default.
• W2013733462 cites W2315228570 @default.
• W2013733462 cites W2615617653 @default.
• W2013733462 doi "https://doi.org/10.1038/modpathol.2012.132" @default.
• W2013733462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22899289" @default.
• W2013733462 hasPublicationYear "2013" @default.
• W2013733462 type Work @default.
• W2013733462 sameAs 2013733462 @default.
• W2013733462 citedByCount "41" @default.
• W2013733462 countsByYear W20137334622013 @default.
• W2013733462 countsByYear W20137334622014 @default.
• W2013733462 countsByYear W20137334622015 @default.
• W2013733462 countsByYear W20137334622016 @default.
• W2013733462 countsByYear W20137334622017 @default.
• W2013733462 countsByYear W20137334622018 @default.
• W2013733462 countsByYear W20137334622019 @default.
• W2013733462 countsByYear W20137334622020 @default.
• W2013733462 countsByYear W20137334622021 @default.
• W2013733462 countsByYear W20137334622022 @default.
• W2013733462 countsByYear W20137334622023 @default.
• W2013733462 crossrefType "journal-article" @default.
• W2013733462 hasAuthorship W2013733462A5000872860 @default.
• W2013733462 hasAuthorship W2013733462A5032767831 @default.
• W2013733462 hasAuthorship W2013733462A5051862611 @default.
• W2013733462 hasAuthorship W2013733462A5081067188 @default.
• W2013733462 hasAuthorship W2013733462A5082234194 @default.
• W2013733462 hasBestOaLocation W20137334621 @default.
• W2013733462 hasConcept C104317684 @default.
• W2013733462 hasConcept C121608353 @default.
• W2013733462 hasConcept C126322002 @default.
• W2013733462 hasConcept C136834591 @default.
• W2013733462 hasConcept C142724271 @default.
• W2013733462 hasConcept C2777658100 @default.
• W2013733462 hasConcept C2777738006 @default.
• W2013733462 hasConcept C2777933648 @default.
• W2013733462 hasConcept C2779013556 @default.
• W2013733462 hasConcept C2779323059 @default.
• W2013733462 hasConcept C2779720271 @default.
• W2013733462 hasConcept C2780212769 @default.
• W2013733462 hasConcept C2780849966 @default.
• W2013733462 hasConcept C28328180 @default.
• W2013733462 hasConcept C502942594 @default.
• W2013733462 hasConcept C530470458 @default.
• W2013733462 hasConcept C54355233 @default.
• W2013733462 hasConcept C55493867 @default.
• W2013733462 hasConcept C71924100 @default.
• W2013733462 hasConcept C83330619 @default.
• W2013733462 hasConcept C86339819 @default.
• W2013733462 hasConcept C86803240 @default.
• W2013733462 hasConceptScore W2013733462C104317684 @default.
• W2013733462 hasConceptScore W2013733462C121608353 @default.
• W2013733462 hasConceptScore W2013733462C126322002 @default.
• W2013733462 hasConceptScore W2013733462C136834591 @default.
• W2013733462 hasConceptScore W2013733462C142724271 @default.
• W2013733462 hasConceptScore W2013733462C2777658100 @default.
• W2013733462 hasConceptScore W2013733462C2777738006 @default.
• W2013733462 hasConceptScore W2013733462C2777933648 @default.
• W2013733462 hasConceptScore W2013733462C2779013556 @default.
• W2013733462 hasConceptScore W2013733462C2779323059 @default.
• W2013733462 hasConceptScore W2013733462C2779720271 @default.
• W2013733462 hasConceptScore W2013733462C2780212769 @default.
• W2013733462 hasConceptScore W2013733462C2780849966 @default.
• W2013733462 hasConceptScore W2013733462C28328180 @default.
• W2013733462 hasConceptScore W2013733462C502942594 @default.
• W2013733462 hasConceptScore W2013733462C530470458 @default.
• W2013733462 hasConceptScore W2013733462C54355233 @default.
• W2013733462 hasConceptScore W2013733462C55493867 @default.

• next