FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013734351> ?p ?o ?g. }

• W2013734351 endingPage "869" @default.
• W2013734351 startingPage "862" @default.
• W2013734351 abstract "Summary SCH 51866 is a potent and selective PDE1 and PDE5 inhibitor. The antiplatelet, antiproliferative, and hemodynamic effects of SCH 51866 were compared with those of E4021, a highly selective PDE5 inhibitor. SCH 51866 inhibited PDE1 and PDE5 isozymes with a 50% inhibitory concentration (IC50) of 70 and 60 nM, respectively. SCH 51866 and E4021 inhibited washed human platelet aggregation induced by collagen with an IC50 of 10 and 4 μM, respectively, and attenuated (p < 0.05) the adhesion of 111indium-labeled platelets to the nylon filament-injured rat aorta. The doses of SCH 51866 and E4021 that inhibited platelet adhesion caused significant increases in platelet cyclic guanosine monophosphate (cGMP; p < 0.05). SCH 51866 (1-10 mg/kg, p.o. twice daily) but not E4021 (3-30 mg/kg, p.o. twice daily) inhibited neointima formation in the carotid arteries of spontaneously hypertensive rats (SHRs) subjected to balloon angioplasty. Moreover, SCH 51866 (0.3-10 mg/kg, p.o.) elicited dose-dependent reduction in blood pressure in SHRs, whereas E4021 (3-30 mg/kg, p.o.) did not affect blood pressure in SHRs. In conclusion, the data suggest that inhibition of PDE1 and PDE5 isozymes by SCH 51866 exerts antiplatelet and vascular protective effects. In comparison, inhibition of PDE5 alone by E4021 exhibited antiplatelet effects without affecting neointima formation." @default.
• W2013734351 created "2016-06-24" @default.
• W2013734351 creator A5000734090 @default.
• W2013734351 creator A5011592743 @default.
• W2013734351 creator A5025369455 @default.
• W2013734351 creator A5030933436 @default.
• W2013734351 creator A5035253821 @default.
• W2013734351 creator A5039894397 @default.
• W2013734351 creator A5047815472 @default.
• W2013734351 creator A5049017606 @default.
• W2013734351 creator A5070427580 @default.
• W2013734351 creator A5076828679 @default.
• W2013734351 creator A5085369960 @default.
• W2013734351 date "1996-12-01" @default.
• W2013734351 modified "2023-10-07" @default.
• W2013734351 title "Antiplatelet and Antiproliferative Effects of SCH 51866, a Novel Type 1 and Type 5 Phosphodiesterase Inhibitor" @default.
• W2013734351 cites W1517162073 @default.
• W2013734351 cites W1968133040 @default.
• W2013734351 cites W1977779461 @default.
• W2013734351 cites W1979001293 @default.
• W2013734351 cites W1984095887 @default.
• W2013734351 cites W1987672928 @default.
• W2013734351 cites W1992860067 @default.
• W2013734351 cites W2006705030 @default.
• W2013734351 cites W2009157737 @default.
• W2013734351 cites W2017108592 @default.
• W2013734351 cites W2024531696 @default.
• W2013734351 cites W2026256311 @default.
• W2013734351 cites W2030038351 @default.
• W2013734351 cites W2033758180 @default.
• W2013734351 cites W2046651709 @default.
• W2013734351 cites W2049304187 @default.
• W2013734351 cites W2055312908 @default.
• W2013734351 cites W2061356481 @default.
• W2013734351 cites W2065399599 @default.
• W2013734351 cites W2071057381 @default.
• W2013734351 cites W2071331983 @default.
• W2013734351 cites W2074052803 @default.
• W2013734351 cites W2122009720 @default.
• W2013734351 cites W2137231240 @default.
• W2013734351 cites W2149710118 @default.
• W2013734351 cites W2170352750 @default.
• W2013734351 doi "https://doi.org/10.1097/00005344-199612000-00018" @default.
• W2013734351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8961086" @default.
• W2013734351 hasPublicationYear "1996" @default.
• W2013734351 type Work @default.
• W2013734351 sameAs 2013734351 @default.
• W2013734351 citedByCount "53" @default.
• W2013734351 countsByYear W20137343512012 @default.
• W2013734351 countsByYear W20137343512013 @default.
• W2013734351 countsByYear W20137343512014 @default.
• W2013734351 countsByYear W20137343512016 @default.
• W2013734351 countsByYear W20137343512017 @default.
• W2013734351 countsByYear W20137343512019 @default.
• W2013734351 countsByYear W20137343512021 @default.
• W2013734351 countsByYear W20137343512023 @default.
• W2013734351 crossrefType "journal-article" @default.
• W2013734351 hasAuthorship W2013734351A5000734090 @default.
• W2013734351 hasAuthorship W2013734351A5011592743 @default.
• W2013734351 hasAuthorship W2013734351A5025369455 @default.
• W2013734351 hasAuthorship W2013734351A5030933436 @default.
• W2013734351 hasAuthorship W2013734351A5035253821 @default.
• W2013734351 hasAuthorship W2013734351A5039894397 @default.
• W2013734351 hasAuthorship W2013734351A5047815472 @default.
• W2013734351 hasAuthorship W2013734351A5049017606 @default.
• W2013734351 hasAuthorship W2013734351A5070427580 @default.
• W2013734351 hasAuthorship W2013734351A5076828679 @default.
• W2013734351 hasAuthorship W2013734351A5085369960 @default.
• W2013734351 hasBestOaLocation W20137343511 @default.
• W2013734351 hasConcept C126322002 @default.
• W2013734351 hasConcept C134018914 @default.
• W2013734351 hasConcept C181199279 @default.
• W2013734351 hasConcept C185592680 @default.
• W2013734351 hasConcept C202751555 @default.
• W2013734351 hasConcept C2776766087 @default.
• W2013734351 hasConcept C2776980637 @default.
• W2013734351 hasConcept C2777339539 @default.
• W2013734351 hasConcept C2777752497 @default.
• W2013734351 hasConcept C2777952589 @default.
• W2013734351 hasConcept C2778283817 @default.
• W2013734351 hasConcept C2778583881 @default.
• W2013734351 hasConcept C2780994212 @default.
• W2013734351 hasConcept C519581460 @default.
• W2013734351 hasConcept C55493867 @default.
• W2013734351 hasConcept C62826618 @default.
• W2013734351 hasConcept C71924100 @default.
• W2013734351 hasConcept C84393581 @default.
• W2013734351 hasConcept C89560881 @default.
• W2013734351 hasConcept C98274493 @default.
• W2013734351 hasConceptScore W2013734351C126322002 @default.
• W2013734351 hasConceptScore W2013734351C134018914 @default.
• W2013734351 hasConceptScore W2013734351C181199279 @default.
• W2013734351 hasConceptScore W2013734351C185592680 @default.
• W2013734351 hasConceptScore W2013734351C202751555 @default.
• W2013734351 hasConceptScore W2013734351C2776766087 @default.
• W2013734351 hasConceptScore W2013734351C2776980637 @default.
• W2013734351 hasConceptScore W2013734351C2777339539 @default.
• W2013734351 hasConceptScore W2013734351C2777752497 @default.

• next