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• W2013738945 endingPage "394" @default.
• W2013738945 startingPage "387" @default.
• W2013738945 abstract "The expression of CD95 (Fas/APO‐1) on B cells has been shown to play a direct role in their fate. B␣cells that chronically bind antigen due to prolonged antigen exposure, such as self‐reactive B cells, are induced to express CD95 by CD40 ligand (CD40L) and are subsequently eliminated by CD95 ligand (CD95L) when they present antigen to CD4 + T cells. B cells that bind antigen acutely due to sudden antigen encounter, such as foreign antigen reactive B cells, up‐regulate CD95, but are normally protected from CD95L‐mediated apoptosis. Here, however, it is shown in vivo that foreign antigen‐specific B cells fail to be protected from CD95‐dependent elimination in a host that is CD95 deficient, regardless of antigenic challenge. These data indicate that B cell antigen receptor (BCR)‐induced protection against CD95L‐mediated apoptosis is not absolute but depends upon other micro‐environmental factors in vivo . The normal balance between T cell‐dependent humoral immunity and tolerance is thus regulated intrinsically by CD95 expression on responding B cells, and extrinsically by CD95‐mediated control of CD95L or other molecules in the lymphoid micro‐environment." @default.
• W2013738945 created "2016-06-24" @default.
• W2013738945 creator A5056373193 @default.
• W2013738945 creator A5070851567 @default.
• W2013738945 date "1998-10-01" @default.
• W2013738945 modified "2023-09-30" @default.
• W2013738945 title "The<i>in vivo</i>balance between B cell clonal expansion and elimination is regulated by CD95 both on B cells and in their micro-environment" @default.
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• W2013738945 doi "https://doi.org/10.1046/j.1440-1711.1998.00774.x" @default.
• W2013738945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9797457" @default.
• W2013738945 hasPublicationYear "1998" @default.
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