FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013740193> ?p ?o ?g. }

• W2013740193 endingPage "148" @default.
• W2013740193 startingPage "133" @default.
• W2013740193 abstract "Quantitation of protein-benzo[a]pyrene adducts represent a more sensitive analysis method than quantitation of benzo[a]pyrene-DNA adducts. By accurate analysis of benzo[a]pyrene-protein adducts several different molecular adduct forms can be studied. Male Wistar rats were injected i.p. with benzo[a]pyrene, and serum albumin was isolated and subjected to acid hydrolysis at 90 degrees C for 3 h. The hydrolysate was analyzed by HPLC with fluorescence detection. The HPLC profiles obtained after albumin hydrolysis from benzo[a]pyrene exposed animals were compared to similar HPLC profiles from in vitro adducted bovine serum albumin (BSA) and direct hydrolysis of both r-10,t-9-dihydrodiol-c-7,8-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (syn-BPDE-III) and r-10,t-9-t-dihydrodiol-t-7,8-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE-III). After acid hydrolysis of albumin from benzo[a]pyrene exposed rats, 6 fluorescent peaks were separated. Four of the peaks were isomers of benzo[a]pyrene-tetrahydrotetrols, (+/-)-benzo[a]pyrene-r-7,t-8,9,10-tetrahydrotetrol, (+/-)-benzo[a]pyrene-r-7,t-8,9,c-10-tetrahydrotetrol, (+/-)-benzo[a]pyrene-r-7,t-8,c-9,t-10-tetrahydrotetrol and (+/-)-benzo[a]pyrene-r-7,t-8,c-9,10-tetrahydrotetrol. In addition we found two fluorescent peaks, named X1 and X2 with retention times similar to the benzo[a]pyrene-tetrols. The unknown fluorescent peaks reacted similar to the four known tetrols in both dose response experiments and time course experiments. Fluorescent material with retention times equal to X1 and X2 were found after acid hydrolysis of syn-BPDE-III and anti-BPDE-III in acid and in hydrolysates from BSA treated in vitro with syn-BPDE-III and anti-BPDE-III. The ratio X1/X2 was relatively constant indicating epimerization equilibrium between these to species. Synchronous fluorescence analysis of fractions containing X1 or X2 from both in vivo and in vitro experiments showed fluorescence spectra characteristic of benzo[a]pyrene tetrols using a wavelength difference of 34 nm." @default.
• W2013740193 created "2016-06-24" @default.
• W2013740193 creator A5007059239 @default.
• W2013740193 creator A5012263259 @default.
• W2013740193 creator A5031035593 @default.
• W2013740193 creator A5044859794 @default.
• W2013740193 date "1999-11-01" @default.
• W2013740193 modified "2023-10-17" @default.
• W2013740193 title "HPLC analysis of benzo[a]pyrene-albumin adducts in benzo[a]pyrene exposed rats. Detection of cis-tetrols arising from hydrolysis of adducts of anti- and syn-BPDE-III with proteins" @default.
• W2013740193 cites W1974183858 @default.
• W2013740193 cites W1979100093 @default.
• W2013740193 cites W1981883953 @default.
• W2013740193 cites W1993557939 @default.
• W2013740193 cites W1996997351 @default.
• W2013740193 cites W1998880088 @default.
• W2013740193 cites W1999603794 @default.
• W2013740193 cites W2006364161 @default.
• W2013740193 cites W2014011495 @default.
• W2013740193 cites W2016916580 @default.
• W2013740193 cites W2021432690 @default.
• W2013740193 cites W2027613739 @default.
• W2013740193 cites W2039114288 @default.
• W2013740193 cites W2039355354 @default.
• W2013740193 cites W2050528507 @default.
• W2013740193 cites W2060076371 @default.
• W2013740193 cites W2062093570 @default.
• W2013740193 cites W2062380194 @default.
• W2013740193 cites W2071891425 @default.
• W2013740193 cites W2078556154 @default.
• W2013740193 cites W2081136396 @default.
• W2013740193 cites W2092480016 @default.
• W2013740193 cites W2162432685 @default.
• W2013740193 cites W3005352387 @default.
• W2013740193 doi "https://doi.org/10.1016/s0009-2797(99)00129-5" @default.
• W2013740193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10597906" @default.
• W2013740193 hasPublicationYear "1999" @default.
• W2013740193 type Work @default.
• W2013740193 sameAs 2013740193 @default.
• W2013740193 citedByCount "21" @default.
• W2013740193 countsByYear W20137401932012 @default.
• W2013740193 countsByYear W20137401932014 @default.
• W2013740193 countsByYear W20137401932015 @default.
• W2013740193 countsByYear W20137401932016 @default.
• W2013740193 countsByYear W20137401932017 @default.
• W2013740193 crossrefType "journal-article" @default.
• W2013740193 hasAuthorship W2013740193A5007059239 @default.
• W2013740193 hasAuthorship W2013740193A5012263259 @default.
• W2013740193 hasAuthorship W2013740193A5031035593 @default.
• W2013740193 hasAuthorship W2013740193A5044859794 @default.
• W2013740193 hasConcept C108204754 @default.
• W2013740193 hasConcept C165616093 @default.
• W2013740193 hasConcept C178790620 @default.
• W2013740193 hasConcept C179998833 @default.
• W2013740193 hasConcept C185592680 @default.
• W2013740193 hasConcept C2776125364 @default.
• W2013740193 hasConcept C2777538855 @default.
• W2013740193 hasConcept C2778951431 @default.
• W2013740193 hasConcept C28800991 @default.
• W2013740193 hasConcept C43617362 @default.
• W2013740193 hasConcept C55493867 @default.
• W2013740193 hasConcept C71240020 @default.
• W2013740193 hasConcept C86807702 @default.
• W2013740193 hasConcept C94412978 @default.
• W2013740193 hasConceptScore W2013740193C108204754 @default.
• W2013740193 hasConceptScore W2013740193C165616093 @default.
• W2013740193 hasConceptScore W2013740193C178790620 @default.
• W2013740193 hasConceptScore W2013740193C179998833 @default.
• W2013740193 hasConceptScore W2013740193C185592680 @default.
• W2013740193 hasConceptScore W2013740193C2776125364 @default.
• W2013740193 hasConceptScore W2013740193C2777538855 @default.
• W2013740193 hasConceptScore W2013740193C2778951431 @default.
• W2013740193 hasConceptScore W2013740193C28800991 @default.
• W2013740193 hasConceptScore W2013740193C43617362 @default.
• W2013740193 hasConceptScore W2013740193C55493867 @default.
• W2013740193 hasConceptScore W2013740193C71240020 @default.
• W2013740193 hasConceptScore W2013740193C86807702 @default.
• W2013740193 hasConceptScore W2013740193C94412978 @default.
• W2013740193 hasIssue "2" @default.
• W2013740193 hasLocation W20137401931 @default.
• W2013740193 hasLocation W20137401932 @default.
• W2013740193 hasOpenAccess W2013740193 @default.
• W2013740193 hasPrimaryLocation W20137401931 @default.
• W2013740193 hasRelatedWork W1970252759 @default.
• W2013740193 hasRelatedWork W1993712628 @default.
• W2013740193 hasRelatedWork W2013740193 @default.
• W2013740193 hasRelatedWork W2014011495 @default.
• W2013740193 hasRelatedWork W2023172944 @default.
• W2013740193 hasRelatedWork W2030975069 @default.
• W2013740193 hasRelatedWork W2148127443 @default.
• W2013740193 hasRelatedWork W2384629054 @default.
• W2013740193 hasRelatedWork W2802953345 @default.
• W2013740193 hasRelatedWork W1581764004 @default.
• W2013740193 hasVolume "123" @default.
• W2013740193 isParatext "false" @default.
• W2013740193 isRetracted "false" @default.
• W2013740193 magId "2013740193" @default.
• W2013740193 workType "article" @default.