FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013744346> ?p ?o ?g. }

• W2013744346 endingPage "1420" @default.
• W2013744346 startingPage "1414" @default.
• W2013744346 abstract "Purpose To analyze the expression of excision repair cross-complementation group 1 (ERCC1) protein in predicting the clinical outcome of nasopharyngeal carcinoma (NPC). Methods and Materials The histologic specimens of 258 patients with Stage III to IVB nonkeratinizing NPC who were treated with radiotherapy alone (Group I) or concurrent-adjuvant chemoradiotherapy (Group II) were retrieved. Immunostaining on ERCC1 protein was performed. The relationship of ERCC1 expression and clinical outcomes was analyzed. Results The median ERCC1 score (proportion score of positively stained cells times intensity) was 200 (range, 0–300), and ERCC1 expression was defined as high if the score was above the median. In Group I high-score tumor had a statistically lower locoregional failure–free rate (LRFFR) compared with low-score tumor (p < 0.05) but not distant failure–free rate (DFFR) and overall survival (OS). In Group II no statistically differences were noted in LRFFR, DFFR and OS with regard to the ERCC1 expression. Resistance to cisplatin-containing chemotherapy in high–ERCC1 score tumor was not observed in Group II. Interestingly, low-score tumor in Group I achieved similar local and distant control compared with Group II. Multivariate analysis showed that ERCC1 score was an independent prognostic factor in LRFFR (p < 0.05) and approached statistical significance in failure-free survival (p = 0.08) and OS (p = 0.07). Tumor with high ERCC1 score had a 2-fold (95% confidence interval, 1.02–3.85) increased risk of locoregional failure. This may imply an association of ERCC1 expression with the repair of radiation damage. Conclusions High ERCC1 expression predicts poor locoregional control in NPC. Chemotherapy response is not affected by ERCC1 expression. Further validation is required. To analyze the expression of excision repair cross-complementation group 1 (ERCC1) protein in predicting the clinical outcome of nasopharyngeal carcinoma (NPC). The histologic specimens of 258 patients with Stage III to IVB nonkeratinizing NPC who were treated with radiotherapy alone (Group I) or concurrent-adjuvant chemoradiotherapy (Group II) were retrieved. Immunostaining on ERCC1 protein was performed. The relationship of ERCC1 expression and clinical outcomes was analyzed. The median ERCC1 score (proportion score of positively stained cells times intensity) was 200 (range, 0–300), and ERCC1 expression was defined as high if the score was above the median. In Group I high-score tumor had a statistically lower locoregional failure–free rate (LRFFR) compared with low-score tumor (p < 0.05) but not distant failure–free rate (DFFR) and overall survival (OS). In Group II no statistically differences were noted in LRFFR, DFFR and OS with regard to the ERCC1 expression. Resistance to cisplatin-containing chemotherapy in high–ERCC1 score tumor was not observed in Group II. Interestingly, low-score tumor in Group I achieved similar local and distant control compared with Group II. Multivariate analysis showed that ERCC1 score was an independent prognostic factor in LRFFR (p < 0.05) and approached statistical significance in failure-free survival (p = 0.08) and OS (p = 0.07). Tumor with high ERCC1 score had a 2-fold (95% confidence interval, 1.02–3.85) increased risk of locoregional failure. This may imply an association of ERCC1 expression with the repair of radiation damage. High ERCC1 expression predicts poor locoregional control in NPC. Chemotherapy response is not affected by ERCC1 expression. Further validation is required." @default.
• W2013744346 created "2016-06-24" @default.
• W2013744346 creator A5016090230 @default.
• W2013744346 creator A5026588958 @default.
• W2013744346 creator A5043514833 @default.
• W2013744346 creator A5055610535 @default.
• W2013744346 creator A5068874466 @default.
• W2013744346 creator A5073544115 @default.
• W2013744346 creator A5083103351 @default.
• W2013744346 date "2011-04-01" @default.
• W2013744346 modified "2023-10-01" @default.
• W2013744346 title "Can the Analysis of ERCC1 Expression Contribute to Individualized Therapy in Nasopharyngeal Carcinoma?" @default.
• W2013744346 cites W1974753377 @default.
• W2013744346 cites W1980630930 @default.
• W2013744346 cites W2000617239 @default.
• W2013744346 cites W2004718750 @default.
• W2013744346 cites W2014401523 @default.
• W2013744346 cites W2049903904 @default.
• W2013744346 cites W2053055917 @default.
• W2013744346 cites W2065829703 @default.
• W2013744346 cites W2094337557 @default.
• W2013744346 cites W2097091932 @default.
• W2013744346 cites W2097294590 @default.
• W2013744346 cites W2106515413 @default.
• W2013744346 cites W2111766542 @default.
• W2013744346 cites W2123315156 @default.
• W2013744346 cites W2125919881 @default.
• W2013744346 cites W2130599429 @default.
• W2013744346 cites W2130730147 @default.
• W2013744346 cites W2146315576 @default.
• W2013744346 cites W2146900413 @default.
• W2013744346 cites W2157004858 @default.
• W2013744346 cites W2158776902 @default.
• W2013744346 cites W2161612574 @default.
• W2013744346 cites W2162505010 @default.
• W2013744346 cites W2164907901 @default.
• W2013744346 cites W2169965886 @default.
• W2013744346 cites W4211054829 @default.
• W2013744346 doi "https://doi.org/10.1016/j.ijrobp.2009.12.072" @default.
• W2013744346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20605357" @default.
• W2013744346 hasPublicationYear "2011" @default.
• W2013744346 type Work @default.
• W2013744346 sameAs 2013744346 @default.
• W2013744346 citedByCount "21" @default.
• W2013744346 countsByYear W20137443462012 @default.
• W2013744346 countsByYear W20137443462013 @default.
• W2013744346 countsByYear W20137443462014 @default.
• W2013744346 countsByYear W20137443462015 @default.
• W2013744346 countsByYear W20137443462017 @default.
• W2013744346 countsByYear W20137443462019 @default.
• W2013744346 countsByYear W20137443462020 @default.
• W2013744346 crossrefType "journal-article" @default.
• W2013744346 hasAuthorship W2013744346A5016090230 @default.
• W2013744346 hasAuthorship W2013744346A5026588958 @default.
• W2013744346 hasAuthorship W2013744346A5043514833 @default.
• W2013744346 hasAuthorship W2013744346A5055610535 @default.
• W2013744346 hasAuthorship W2013744346A5068874466 @default.
• W2013744346 hasAuthorship W2013744346A5073544115 @default.
• W2013744346 hasAuthorship W2013744346A5083103351 @default.
• W2013744346 hasConcept C104317684 @default.
• W2013744346 hasConcept C104451858 @default.
• W2013744346 hasConcept C126322002 @default.
• W2013744346 hasConcept C134935766 @default.
• W2013744346 hasConcept C143998085 @default.
• W2013744346 hasConcept C185592680 @default.
• W2013744346 hasConcept C2776694085 @default.
• W2013744346 hasConcept C2778239845 @default.
• W2013744346 hasConcept C2778424827 @default.
• W2013744346 hasConcept C2778997737 @default.
• W2013744346 hasConcept C2779309665 @default.
• W2013744346 hasConcept C44249647 @default.
• W2013744346 hasConcept C509974204 @default.
• W2013744346 hasConcept C55493867 @default.
• W2013744346 hasConcept C71924100 @default.
• W2013744346 hasConceptScore W2013744346C104317684 @default.
• W2013744346 hasConceptScore W2013744346C104451858 @default.
• W2013744346 hasConceptScore W2013744346C126322002 @default.
• W2013744346 hasConceptScore W2013744346C134935766 @default.
• W2013744346 hasConceptScore W2013744346C143998085 @default.
• W2013744346 hasConceptScore W2013744346C185592680 @default.
• W2013744346 hasConceptScore W2013744346C2776694085 @default.
• W2013744346 hasConceptScore W2013744346C2778239845 @default.
• W2013744346 hasConceptScore W2013744346C2778424827 @default.
• W2013744346 hasConceptScore W2013744346C2778997737 @default.
• W2013744346 hasConceptScore W2013744346C2779309665 @default.
• W2013744346 hasConceptScore W2013744346C44249647 @default.
• W2013744346 hasConceptScore W2013744346C509974204 @default.
• W2013744346 hasConceptScore W2013744346C55493867 @default.
• W2013744346 hasConceptScore W2013744346C71924100 @default.
• W2013744346 hasIssue "5" @default.
• W2013744346 hasLocation W20137443461 @default.
• W2013744346 hasLocation W20137443462 @default.
• W2013744346 hasOpenAccess W2013744346 @default.
• W2013744346 hasPrimaryLocation W20137443461 @default.
• W2013744346 hasRelatedWork W2358752229 @default.
• W2013744346 hasRelatedWork W2363044209 @default.
• W2013744346 hasRelatedWork W2365209765 @default.
• W2013744346 hasRelatedWork W2372838325 @default.

• next