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- W2013749877 abstract "Purpose: The purpose of this study was to evaluate the effects of intravitreal injection of ICG (indocyanine green), TB (trypan blue) and TA (triamcinolone acetonide) on the visual function assessed by electroretinogram (ERG) in the rat. Methods: Three groups of 12-week-old Sprague Dawley rats (n=6) received intravitreal injection in one eye of 0.1mL of either ICG 0.5mg/mL, TB 3mg/mL or TA 40mg/mL followed by a rinse with 1mL of saline solution. The controlateral eye was used as a control and was injected similarly with saline only. The scotopic ERG was recorded at different intensities (10mcds/m², 2500mcds/m² and 25000mcds/m²) before injection and 28 days after treatment. Results: No effect of the treatment was observed on the ERG amplitudes and wave latencies in control eyes and in eyes treated with TB and TA. The ERG b-wave amplitudes and latencies were significantly reduced in eyes treated with ICG at 10mcds/m² and 2500mcds/m² but not at 25000mcds/m² (amplitude means: t0=174.8μV versus t28=55.0μV at 10mcds/m² p<0.05; t0=176.5μV versus t28=70.0μV at 2500mcds/m² p<0.05; t0=140.3μV versus t28=40.0μV at 25000mcds/m² p=0.057). The ERG a-wave amplitudes and latencies were also significantly lowered at 2500mcds/m² in eyes treated with ICG (amplitude means: t0=45.0μV versus t28=23μV p<0.05; latency means: t0=7.6msec versus t28=9.5msec p<0.01). Conclusions: This study shows a side effect of ICG on retinal function four weeks after a transient retinal exposure. TA and TB could be considered as interesting alternatives to ICG for macular surgery." @default.
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- W2013749877 date "2007-10-02" @default.
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- W2013749877 title "Effect of intravitreal injection of indocyanine green, triamcinolone acetonide and trypan blue on the electroretinographic response in the rat" @default.
- W2013749877 doi "https://doi.org/10.1111/j.1600-0420.2007.01062_3137.x" @default.
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