FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013753203> ?p ?o ?g. }

• W2013753203 endingPage "138" @default.
• W2013753203 startingPage "132" @default.
• W2013753203 abstract "An efficient and reliable enantioseparation method by high-performance liquid chromatography (HPLC) for the chiral herbicide diclofop-methyl (DM) and its primary metabolite diclofop (DC) was developed and validated, and the biological process of the enantiomers in loach liver microsomes (LLM) in vitro was investigated. The enantiomers of DM and DC were first separated on an immobilized-type stationary phase of Chiralpak IC. The best resolutions were achieved under the chromatographic condition of n-hexane/IPA/TFA 96:4:0.1(v/v/v) at 20 °C with each Rs > 2 and the two pairs of enantiomers could be eluted in about 10 min. The extraction recoveries of the analytes from LLM were 79.6–108.9% with RSD ≤ 11.5%. The enzyme kinetics of DM enantiomers were different, with the Km value 320.7 for (S)-DM and 392.1 for (R)-DM. The metabolism experiment in vitro showed DM underwent a rapid phase-I metabolism with or without NADPH, indicating the esterases in liver played a dominant role. No interconversion between the two enantiomers was observed by single-enantiomer incubation. The preferential degradation of (S)-DM was confirmed with the half-time (t1/2) of (S)-DM 5.27 min and 21.2 min for (R)-DM. DC enantiomer was generated by its corresponding ester form and could not be further degraded during the incubation. It was the first study on biotransformation of DM and DC enantiomers in LLM in vitro. The results may help to evaluate the ecological risks of chiral pesticides." @default.
• W2013753203 created "2016-06-24" @default.
• W2013753203 creator A5000361082 @default.
• W2013753203 creator A5036694563 @default.
• W2013753203 creator A5060753195 @default.
• W2013753203 creator A5081567007 @default.
• W2013753203 creator A5083803152 @default.
• W2013753203 creator A5084974862 @default.
• W2013753203 creator A5089872805 @default.
• W2013753203 date "2014-10-01" @default.
• W2013753203 modified "2023-10-17" @default.
• W2013753203 title "Enantioselective metabolism of the chiral herbicide diclofop-methyl and diclofop by HPLC in loach (Misgurnus anguillicaudatus) liver microsomes in vitro" @default.
• W2013753203 cites W1483970630 @default.
• W2013753203 cites W1967475766 @default.
• W2013753203 cites W1968029998 @default.
• W2013753203 cites W1978655020 @default.
• W2013753203 cites W1984527055 @default.
• W2013753203 cites W1986652242 @default.
• W2013753203 cites W1991783433 @default.
• W2013753203 cites W1992110113 @default.
• W2013753203 cites W1995085526 @default.
• W2013753203 cites W1998458258 @default.
• W2013753203 cites W2007112953 @default.
• W2013753203 cites W2012968531 @default.
• W2013753203 cites W2021777494 @default.
• W2013753203 cites W2031885978 @default.
• W2013753203 cites W2043616181 @default.
• W2013753203 cites W2046109662 @default.
• W2013753203 cites W2048349264 @default.
• W2013753203 cites W2055121554 @default.
• W2013753203 cites W2058299680 @default.
• W2013753203 cites W2065182815 @default.
• W2013753203 cites W2074547921 @default.
• W2013753203 cites W2076216973 @default.
• W2013753203 cites W2084485034 @default.
• W2013753203 cites W2086356649 @default.
• W2013753203 cites W2086404451 @default.
• W2013753203 cites W2100015387 @default.
• W2013753203 cites W2119233246 @default.
• W2013753203 cites W2469775252 @default.
• W2013753203 doi "https://doi.org/10.1016/j.jchromb.2014.08.014" @default.
• W2013753203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25173494" @default.
• W2013753203 hasPublicationYear "2014" @default.
• W2013753203 type Work @default.
• W2013753203 sameAs 2013753203 @default.
• W2013753203 citedByCount "13" @default.
• W2013753203 countsByYear W20137532032015 @default.
• W2013753203 countsByYear W20137532032016 @default.
• W2013753203 countsByYear W20137532032018 @default.
• W2013753203 countsByYear W20137532032019 @default.
• W2013753203 countsByYear W20137532032020 @default.
• W2013753203 countsByYear W20137532032021 @default.
• W2013753203 countsByYear W20137532032022 @default.
• W2013753203 countsByYear W20137532032023 @default.
• W2013753203 crossrefType "journal-article" @default.
• W2013753203 hasAuthorship W2013753203A5000361082 @default.
• W2013753203 hasAuthorship W2013753203A5036694563 @default.
• W2013753203 hasAuthorship W2013753203A5060753195 @default.
• W2013753203 hasAuthorship W2013753203A5081567007 @default.
• W2013753203 hasAuthorship W2013753203A5083803152 @default.
• W2013753203 hasAuthorship W2013753203A5084974862 @default.
• W2013753203 hasAuthorship W2013753203A5089872805 @default.
• W2013753203 hasConcept C16838498 @default.
• W2013753203 hasConcept C179998833 @default.
• W2013753203 hasConcept C181199279 @default.
• W2013753203 hasConcept C185592680 @default.
• W2013753203 hasConcept C202751555 @default.
• W2013753203 hasConcept C2777477808 @default.
• W2013753203 hasConcept C27881333 @default.
• W2013753203 hasConcept C43617362 @default.
• W2013753203 hasConcept C486523 @default.
• W2013753203 hasConcept C55493867 @default.
• W2013753203 hasConcept C62231903 @default.
• W2013753203 hasConcept C71240020 @default.
• W2013753203 hasConcept C87644729 @default.
• W2013753203 hasConceptScore W2013753203C16838498 @default.
• W2013753203 hasConceptScore W2013753203C179998833 @default.
• W2013753203 hasConceptScore W2013753203C181199279 @default.
• W2013753203 hasConceptScore W2013753203C185592680 @default.
• W2013753203 hasConceptScore W2013753203C202751555 @default.
• W2013753203 hasConceptScore W2013753203C2777477808 @default.
• W2013753203 hasConceptScore W2013753203C27881333 @default.
• W2013753203 hasConceptScore W2013753203C43617362 @default.
• W2013753203 hasConceptScore W2013753203C486523 @default.
• W2013753203 hasConceptScore W2013753203C55493867 @default.
• W2013753203 hasConceptScore W2013753203C62231903 @default.
• W2013753203 hasConceptScore W2013753203C71240020 @default.
• W2013753203 hasConceptScore W2013753203C87644729 @default.
• W2013753203 hasFunder F4320321001 @default.
• W2013753203 hasFunder F4320321769 @default.
• W2013753203 hasFunder F4320334924 @default.
• W2013753203 hasLocation W20137532031 @default.
• W2013753203 hasLocation W20137532032 @default.
• W2013753203 hasOpenAccess W2013753203 @default.
• W2013753203 hasPrimaryLocation W20137532031 @default.
• W2013753203 hasRelatedWork W1989575556 @default.
• W2013753203 hasRelatedWork W2021792606 @default.
• W2013753203 hasRelatedWork W2087639700 @default.

• next