FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013753338> ?p ?o ?g. }

• W2013753338 abstract "CARMA1-mediated NF-κB activation controls lymphocyte activation through antigen receptors and survival of some malignant lymphomas. CARMA1 clusters are formed on physiological receptor-mediated activation or by its oncogenic mutation in activated B-cell-diffuse large B-cell lymphomas (ABC-DLBCLs) with constitutive NF-κB activation. However, regulatory mechanisms and relevance of CARMA1 clusters in the NF-κB pathway are unclear. Here we show that SH3 and GUK domain interactions of CARMA1 link CARMA1 clustering to signal activation. SH3 and GUK domains of CARMA1 interact by either intra- or intermolecular mechanisms, which are required for activation-induced assembly of CARMA1. Disruption of these interactions abolishes the formation of CARMA1 microclusters at the immunological synapse, CARMA-regulated signal activation following antigen receptor stimulation as well as spontaneous CARMA1 clustering and NF-κB activation by the oncogenic CARMA1 mutation in ABC-DLBCLs. Thus, the SH3–GUK interactions that regulate CARMA1 cluster formations are promising therapeutic targets for ABC-DLBCLs. Activating mutations in the NF-κB regulator CARMA1 are associated with a form of B-cell lymphoma. Hara et al. show that both physiological and oncogenic CARMA1 signalling can be inhibited by preventing its activation-induced clustering, which is mediated by its SH3 and GUK domains." @default.
• W2013753338 created "2016-06-24" @default.
• W2013753338 creator A5003553383 @default.
• W2013753338 creator A5009425156 @default.
• W2013753338 creator A5036666969 @default.
• W2013753338 creator A5045437023 @default.
• W2013753338 creator A5046136308 @default.
• W2013753338 creator A5069790125 @default.
• W2013753338 creator A5074322958 @default.
• W2013753338 creator A5074352292 @default.
• W2013753338 creator A5087988071 @default.
• W2013753338 date "2015-01-20" @default.
• W2013753338 modified "2023-09-27" @default.
• W2013753338 title "Clustering of CARMA1 through SH3–GUK domain interactions is required for its activation of NF-κB signalling" @default.
• W2013753338 cites W1537427513 @default.
• W2013753338 cites W1963928863 @default.
• W2013753338 cites W1964412713 @default.
• W2013753338 cites W1977642281 @default.
• W2013753338 cites W1981280629 @default.
• W2013753338 cites W1984647008 @default.
• W2013753338 cites W1985372425 @default.
• W2013753338 cites W1986191025 @default.
• W2013753338 cites W1996699413 @default.
• W2013753338 cites W1999500196 @default.
• W2013753338 cites W2008516360 @default.
• W2013753338 cites W2013054583 @default.
• W2013753338 cites W2013862100 @default.
• W2013753338 cites W2016246269 @default.
• W2013753338 cites W2020045401 @default.
• W2013753338 cites W2029946033 @default.
• W2013753338 cites W2031855605 @default.
• W2013753338 cites W2031967183 @default.
• W2013753338 cites W2032997139 @default.
• W2013753338 cites W2033036939 @default.
• W2013753338 cites W2041161178 @default.
• W2013753338 cites W2043153946 @default.
• W2013753338 cites W2065283382 @default.
• W2013753338 cites W2066177415 @default.
• W2013753338 cites W2083380661 @default.
• W2013753338 cites W2083391898 @default.
• W2013753338 cites W2083498707 @default.
• W2013753338 cites W2083682993 @default.
• W2013753338 cites W2084737863 @default.
• W2013753338 cites W2092977634 @default.
• W2013753338 cites W2096234619 @default.
• W2013753338 cites W2096308522 @default.
• W2013753338 cites W2096977835 @default.
• W2013753338 cites W2101625485 @default.
• W2013753338 cites W2103048744 @default.
• W2013753338 cites W2103093241 @default.
• W2013753338 cites W2103994181 @default.
• W2013753338 cites W2105196805 @default.
• W2013753338 cites W2116946576 @default.
• W2013753338 cites W2117095174 @default.
• W2013753338 cites W2120587971 @default.
• W2013753338 cites W2132365739 @default.
• W2013753338 cites W2136372907 @default.
• W2013753338 cites W2137015675 @default.
• W2013753338 cites W2137823685 @default.
• W2013753338 cites W2139792086 @default.
• W2013753338 cites W2142159344 @default.
• W2013753338 cites W2150955780 @default.
• W2013753338 cites W2157710443 @default.
• W2013753338 cites W2163716168 @default.
• W2013753338 cites W2166248172 @default.
• W2013753338 cites W2169803769 @default.
• W2013753338 cites W2170177157 @default.
• W2013753338 cites W2608724752 @default.
• W2013753338 cites W4236101324 @default.
• W2013753338 doi "https://doi.org/10.1038/ncomms6555" @default.
• W2013753338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25602919" @default.
• W2013753338 hasPublicationYear "2015" @default.
• W2013753338 type Work @default.
• W2013753338 sameAs 2013753338 @default.
• W2013753338 citedByCount "21" @default.
• W2013753338 countsByYear W20137533382016 @default.
• W2013753338 countsByYear W20137533382017 @default.
• W2013753338 countsByYear W20137533382018 @default.
• W2013753338 countsByYear W20137533382019 @default.
• W2013753338 countsByYear W20137533382020 @default.
• W2013753338 countsByYear W20137533382021 @default.
• W2013753338 countsByYear W20137533382022 @default.
• W2013753338 countsByYear W20137533382023 @default.
• W2013753338 crossrefType "journal-article" @default.
• W2013753338 hasAuthorship W2013753338A5003553383 @default.
• W2013753338 hasAuthorship W2013753338A5009425156 @default.
• W2013753338 hasAuthorship W2013753338A5036666969 @default.
• W2013753338 hasAuthorship W2013753338A5045437023 @default.
• W2013753338 hasAuthorship W2013753338A5046136308 @default.
• W2013753338 hasAuthorship W2013753338A5069790125 @default.
• W2013753338 hasAuthorship W2013753338A5074322958 @default.
• W2013753338 hasAuthorship W2013753338A5074352292 @default.
• W2013753338 hasAuthorship W2013753338A5087988071 @default.
• W2013753338 hasBestOaLocation W20137533381 @default.
• W2013753338 hasConcept C144647389 @default.
• W2013753338 hasConcept C172078151 @default.
• W2013753338 hasConcept C183786373 @default.
• W2013753338 hasConcept C41625074 @default.
• W2013753338 hasConcept C54355233 @default.
• W2013753338 hasConcept C62478195 @default.

• next