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• W2013754265 abstract "The concept of molecular simplification as a drug design strategy to shorten synthetic routes, while keeping or enhancing the biological activity of the lead drug, has been applied to (+)-muconin, an acetogenin with remarkable cytotoxicity. A novel approach that enables the stereoselective synthesis of such a natural compound or its enantiomer from a common precursor is described. An additional advantage of the method is complete stereochemical control and the decrease in the number of chemical steps required, thus providing an enhancement of the overall yield. Antiproliferative studies against the human solid tumor cell lines showed that the aliphatic chain-THF/THP fragment of (+)-muconin has modest cytotoxic activity. The strategy opens the way to preparing novel bioactive acetogenin analogues by shorter synthetic routes." @default.
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• W2013754265 date "2006-02-11" @default.
• W2013754265 modified "2023-10-06" @default.
• W2013754265 title "Molecular Simplification in Bioactive Molecules: Formal Synthesis of (+)-Muconin" @default.
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• W2013754265 doi "https://doi.org/10.1021/jo0524674" @default.
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