FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013754906> ?p ?o ?g. }

• W2013754906 endingPage "8024" @default.
• W2013754906 startingPage "8013" @default.
• W2013754906 abstract "Precise targeting and maintenance of axonal domains in myelinated axons is essential for saltatory conduction. Caspr and Caspr2, which localize at paranodal and juxtaparanodal domains, contain binding sites for the cytoskeletal adaptor protein 4.1B. The exact role of 4.1B in the organization and maintenance of axonal domains is still not clear. Here, we report the generation and characterization of 4.1B -null mice. We show that loss of 4.1B in the PNS results in mislocalization of Caspr at paranodes and destabilization of paranodal axoglial septate junctions (AGSJs) as early as postnatal day 30. In the CNS, Caspr localization is progressively disrupted and ultrastructural analysis showed paranodal regions that were completely devoid of AGSJs, with axolemma separated from the myelin loops, and loops coming off the axolemma. Most importantly, our phenotypic analysis of previously generated 4.1B mutants, used in the study by Horresh et al. (2010), showed that Caspr localization was not affected in the PNS, even after 1 year; and 4.1R was neither expressed, nor enriched at the paranodes. Furthermore, ultrastructural analysis of these 4.1B mutants showed destabilization of CNS AGSJs at ∼1 year. We also discovered that the 4.1B locus is differentially expressed in the PNS and CNS, and generates multiple splice isoforms in the PNS, suggesting 4.1B may function differently in the PNS versus CNS. Together, our studies provide direct evidence that 4.1B plays a pivotal role in interactions between the paranodal AGSJs and axonal cytoskeleton, and that 4.1B is critically required for long-term maintenance of axonal domains in myelinated axons." @default.
• W2013754906 created "2016-06-24" @default.
• W2013754906 creator A5012364233 @default.
• W2013754906 creator A5017948966 @default.
• W2013754906 creator A5042844951 @default.
• W2013754906 creator A5065959288 @default.
• W2013754906 creator A5078312882 @default.
• W2013754906 creator A5085020669 @default.
• W2013754906 date "2011-06-01" @default.
• W2013754906 modified "2023-10-15" @default.
• W2013754906 title "The Cytoskeletal Adaptor Protein Band 4.1B Is Required for the Maintenance of Paranodal Axoglial Septate Junctions in Myelinated Axons" @default.
• W2013754906 cites W189211965 @default.
• W2013754906 cites W1966721481 @default.
• W2013754906 cites W1969757253 @default.
• W2013754906 cites W1979231988 @default.
• W2013754906 cites W1979651668 @default.
• W2013754906 cites W1982110038 @default.
• W2013754906 cites W1990219082 @default.
• W2013754906 cites W1990979543 @default.
• W2013754906 cites W1999106225 @default.
• W2013754906 cites W2006129591 @default.
• W2013754906 cites W2007110951 @default.
• W2013754906 cites W2011028001 @default.
• W2013754906 cites W2014139274 @default.
• W2013754906 cites W2018581446 @default.
• W2013754906 cites W2029914998 @default.
• W2013754906 cites W2037077904 @default.
• W2013754906 cites W2040310469 @default.
• W2013754906 cites W2041388242 @default.
• W2013754906 cites W2047990013 @default.
• W2013754906 cites W2059241499 @default.
• W2013754906 cites W2069455944 @default.
• W2013754906 cites W2081005556 @default.
• W2013754906 cites W2102472951 @default.
• W2013754906 cites W2118478594 @default.
• W2013754906 cites W2120687426 @default.
• W2013754906 cites W2122971055 @default.
• W2013754906 cites W2124921662 @default.
• W2013754906 cites W2128367954 @default.
• W2013754906 cites W2133787519 @default.
• W2013754906 cites W2140501411 @default.
• W2013754906 cites W2143646720 @default.
• W2013754906 cites W2143699287 @default.
• W2013754906 cites W2149834909 @default.
• W2013754906 cites W2151763534 @default.
• W2013754906 cites W2156134210 @default.
• W2013754906 cites W2157442664 @default.
• W2013754906 cites W350368777 @default.
• W2013754906 cites W48470489 @default.
• W2013754906 doi "https://doi.org/10.1523/jneurosci.1015-11.2011" @default.
• W2013754906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3121702" @default.
• W2013754906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21632923" @default.
• W2013754906 hasPublicationYear "2011" @default.
• W2013754906 type Work @default.
• W2013754906 sameAs 2013754906 @default.
• W2013754906 citedByCount "51" @default.
• W2013754906 countsByYear W20137549062012 @default.
• W2013754906 countsByYear W20137549062013 @default.
• W2013754906 countsByYear W20137549062014 @default.
• W2013754906 countsByYear W20137549062015 @default.
• W2013754906 countsByYear W20137549062016 @default.
• W2013754906 countsByYear W20137549062017 @default.
• W2013754906 countsByYear W20137549062018 @default.
• W2013754906 countsByYear W20137549062019 @default.
• W2013754906 countsByYear W20137549062020 @default.
• W2013754906 countsByYear W20137549062021 @default.
• W2013754906 countsByYear W20137549062022 @default.
• W2013754906 countsByYear W20137549062023 @default.
• W2013754906 crossrefType "journal-article" @default.
• W2013754906 hasAuthorship W2013754906A5012364233 @default.
• W2013754906 hasAuthorship W2013754906A5017948966 @default.
• W2013754906 hasAuthorship W2013754906A5042844951 @default.
• W2013754906 hasAuthorship W2013754906A5065959288 @default.
• W2013754906 hasAuthorship W2013754906A5078312882 @default.
• W2013754906 hasAuthorship W2013754906A5085020669 @default.
• W2013754906 hasBestOaLocation W20137549061 @default.
• W2013754906 hasConcept C118322738 @default.
• W2013754906 hasConcept C142669718 @default.
• W2013754906 hasConcept C1491633281 @default.
• W2013754906 hasConcept C158157758 @default.
• W2013754906 hasConcept C169760540 @default.
• W2013754906 hasConcept C183786373 @default.
• W2013754906 hasConcept C2777037019 @default.
• W2013754906 hasConcept C2778011777 @default.
• W2013754906 hasConcept C2778609137 @default.
• W2013754906 hasConcept C529278444 @default.
• W2013754906 hasConcept C54355233 @default.
• W2013754906 hasConcept C62478195 @default.
• W2013754906 hasConcept C79879829 @default.
• W2013754906 hasConcept C86803240 @default.
• W2013754906 hasConcept C95444343 @default.
• W2013754906 hasConceptScore W2013754906C118322738 @default.
• W2013754906 hasConceptScore W2013754906C142669718 @default.
• W2013754906 hasConceptScore W2013754906C1491633281 @default.
• W2013754906 hasConceptScore W2013754906C158157758 @default.
• W2013754906 hasConceptScore W2013754906C169760540 @default.
• W2013754906 hasConceptScore W2013754906C183786373 @default.
• W2013754906 hasConceptScore W2013754906C2777037019 @default.

• next