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- W2013755249 abstract "<h3>Objectives</h3> The purpose of this study is to determine the trajectory of lung function change after exposure cessation to occupational organic dust exposure, and to identify factors that modify improvement. <h3>Methods</h3> The Shanghai Textile Worker Study is a longitudinal study of 447 cotton workers exposed to endotoxin-containing dust and 472 silk workers exposed to non-endotoxin-containing dust. Spirometry was performed at 5-year intervals. Air sampling was performed to estimate individual cumulative exposures. The effect of work cessation on forced expiratory volume in 1 s (FEV<sub>1</sub>) was modelled using generalised additive mixed effects models to identify the trajectory of FEV<sub>1</sub> recovery. Linear mixed effects models incorporating interaction terms were used to identify modifiers of FEV<sub>1</sub> recovery. Loss to follow-up was accounted for with inverse probability of censoring weights. <h3>Results</h3> 74.2% of the original cohort still alive participated in 2011. Generalised additive mixed models identified a non-linear improvement in FEV<sub>1</sub> for all workers after exposure cessation, with no plateau noted 25 years after retirement. Linear mixed effects models incorporating interaction terms identified prior endotoxin exposure (p=0.01) and male gender (p=0.002) as risk factors for impaired FEV<sub>1</sub> improvement after exposure cessation. After adjusting for gender, smoking delayed the onset of FEV<sub>1</sub> gain but did not affect the overall magnitude of change. <h3>Conclusions</h3> Lung function improvement after cessation of exposure to organic dust is sustained. Endotoxin exposure and male gender are risk factors for less FEV<sub>1</sub> improvement." @default.
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- W2013755249 date "2015-02-09" @default.
- W2013755249 modified "2023-09-23" @default.
- W2013755249 title "Endotoxin and gender modify lung function recovery after occupational organic dust exposure: a 30-year study" @default.
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- W2013755249 doi "https://doi.org/10.1136/oemed-2014-102579" @default.
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