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- W2013757644 abstract "The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a common feature of all T-cell acute lymphoblastic leukemias (T-ALL). Notch genes, and other genes that are dysregulated in some T-ALL subgroups, encode factors that play a crucial role in both T-cell development and leukemogenesis. A complex network of signals, involving Notchs, pre-TCR, nuclear factor κB and E2A, appears to be responsible for the leukemogenesis process. Thus, T-ALL is a paradigm for developmental pathways that underlie the pathogenesis of this disease." @default.
- W2013757644 created "2016-06-24" @default.
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- W2013757644 date "2003-01-01" @default.
- W2013757644 modified "2023-09-24" @default.
- W2013757644 title "Notch, a unifying target in T-cell acute lymphoblastic leukemia?" @default.
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- W2013757644 doi "https://doi.org/10.1016/s1471-4914(02)00003-5" @default.
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