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- W2013757648 abstract "As candidate genes of attention—deficit/hyperactivity disorder (ADHD), monoamine oxidase A (MAOA), and synaptophysin (SYP) are both on the X chromosome, and have been suggested to be associated with the predominantly inattentive subtype (ADHD-I). The present study is to investigate the potential gene–gene interaction (G × G) between rs5905859 of MAOA and rs5906754 of SYP for ADHD in Chinese Han subjects. For family-based association study, 177 female trios were included. For case-control study, 1,462 probands and 807 normal controls were recruited. The ADHD Rating Scale-IV (ADHD-RS-IV) was used to evaluate ADHD symptoms. Pedigree-based generalized multifactor dimensionality reduction (PGMDR) for female ADHD trios indicated significant gene interaction effect of rs5905859 and rs5906754. Generalized multifactor dimensionality reduction (GMDR) indicated potential gene–gene interplay on ADHD RS-IV scores in female ADHD-I. No associations were observed in male subjects in case-control analysis. In conclusion, our findings suggested that the interaction of MAOA and SYP may be involved in the genetic mechanism of ADHD-I subtype and predict ADHD symptoms. © 2014 Wiley Periodicals, Inc." @default.
- W2013757648 created "2016-06-24" @default.
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- W2013757648 date "2014-12-08" @default.
- W2013757648 modified "2023-10-10" @default.
- W2013757648 title "Interactions betweenMAOAandSYPpolymorphisms were associated with symptoms of attention-deficit/hyperactivity disorder in Chinese Han subjects" @default.
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- W2013757648 doi "https://doi.org/10.1002/ajmg.b.32273" @default.
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