FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013760089> ?p ?o ?g. }

• W2013760089 endingPage "8285" @default.
• W2013760089 startingPage "8278" @default.
• W2013760089 abstract "Arsenic is a carcinogen with transplacental activity that can affect human skin stem cell population dynamics in vitro by blocking exit into differentiation pathways. Keratinocyte stem cells (KSC) are probably a key target in skin carcinogenesis. Thus, we tested the effects of fetal arsenic exposure in Tg.AC mice, a strain sensitive to skin carcinogenesis via activation of the v-Ha-ras transgene likely in KSCs. After fetal arsenic treatment, offspring received topical 12-O-tetradecanoyl phorbol-13-acetate (TPA) through adulthood. Arsenic alone had no effect, whereas TPA alone induced papillomas and squamous cell carcinomas (SCC). However, fetal arsenic treatment before TPA increased SCC multiplicity 3-fold more than TPA alone, and these SCCs were much more aggressive (invasive, etc.). Tumor v-Ha-ras levels were 3-fold higher with arsenic plus TPA than TPA alone, and v-Ha-ras was overexpressed early on in arsenic-treated fetal skin. CD34, considered a marker for both KSCs and skin cancer stem cells, and Rac1, a key gene stimulating KSC self-renewal, were greatly increased in tumors produced by arsenic plus TPA exposure versus TPA alone, and both were elevated in arsenic-treated fetal skin. Greatly increased numbers of CD34-positive probable cancer stem cells and marked overexpression of RAC1 protein occurred in tumors induced by arsenic plus TPA compared with TPA alone. Thus, fetal arsenic exposure, although by itself oncogenically inactive in skin, facilitated cancer response in association with distorted skin tumor stem cell signaling and population dynamics, implicating stem cells as a target of arsenic in the fetal basis of skin cancer in adulthood." @default.
• W2013760089 created "2016-06-24" @default.
• W2013760089 creator A5011194642 @default.
• W2013760089 creator A5042887827 @default.
• W2013760089 creator A5049381682 @default.
• W2013760089 creator A5059651167 @default.
• W2013760089 creator A5061909361 @default.
• W2013760089 creator A5071207779 @default.
• W2013760089 creator A5074661042 @default.
• W2013760089 creator A5085352453 @default.
• W2013760089 creator A5091276205 @default.
• W2013760089 date "2008-10-15" @default.
• W2013760089 modified "2023-10-01" @default.
• W2013760089 title "Arsenic Exposure <i>In utero</i> Exacerbates Skin Cancer Response in Adulthood with Contemporaneous Distortion of Tumor Stem Cell Dynamics" @default.
• W2013760089 cites W1965281877 @default.
• W2013760089 cites W1968704764 @default.
• W2013760089 cites W1969826588 @default.
• W2013760089 cites W1970083046 @default.
• W2013760089 cites W1977087590 @default.
• W2013760089 cites W1978665041 @default.
• W2013760089 cites W1981657350 @default.
• W2013760089 cites W1985114641 @default.
• W2013760089 cites W1985508272 @default.
• W2013760089 cites W2000735835 @default.
• W2013760089 cites W2003205168 @default.
• W2013760089 cites W2009317934 @default.
• W2013760089 cites W2009565292 @default.
• W2013760089 cites W2017779792 @default.
• W2013760089 cites W2028166249 @default.
• W2013760089 cites W2030918212 @default.
• W2013760089 cites W2031052102 @default.
• W2013760089 cites W2036041106 @default.
• W2013760089 cites W2037882440 @default.
• W2013760089 cites W2048520512 @default.
• W2013760089 cites W2052305135 @default.
• W2013760089 cites W2056562063 @default.
• W2013760089 cites W2059694060 @default.
• W2013760089 cites W2064343777 @default.
• W2013760089 cites W2064912565 @default.
• W2013760089 cites W2087413829 @default.
• W2013760089 cites W2088823531 @default.
• W2013760089 cites W2090514887 @default.
• W2013760089 cites W2111522563 @default.
• W2013760089 cites W2142105477 @default.
• W2013760089 cites W2143847855 @default.
• W2013760089 cites W2150058256 @default.
• W2013760089 cites W2159956387 @default.
• W2013760089 cites W2169752217 @default.
• W2013760089 cites W2244256850 @default.
• W2013760089 cites W4301457571 @default.
• W2013760089 doi "https://doi.org/10.1158/0008-5472.can-08-2099" @default.
• W2013760089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2652700" @default.
• W2013760089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18922899" @default.
• W2013760089 hasPublicationYear "2008" @default.
• W2013760089 type Work @default.
• W2013760089 sameAs 2013760089 @default.
• W2013760089 citedByCount "92" @default.
• W2013760089 countsByYear W20137600892012 @default.
• W2013760089 countsByYear W20137600892013 @default.
• W2013760089 countsByYear W20137600892014 @default.
• W2013760089 countsByYear W20137600892015 @default.
• W2013760089 countsByYear W20137600892016 @default.
• W2013760089 countsByYear W20137600892017 @default.
• W2013760089 countsByYear W20137600892018 @default.
• W2013760089 countsByYear W20137600892019 @default.
• W2013760089 countsByYear W20137600892020 @default.
• W2013760089 countsByYear W20137600892021 @default.
• W2013760089 countsByYear W20137600892022 @default.
• W2013760089 countsByYear W20137600892023 @default.
• W2013760089 crossrefType "journal-article" @default.
• W2013760089 hasAuthorship W2013760089A5011194642 @default.
• W2013760089 hasAuthorship W2013760089A5042887827 @default.
• W2013760089 hasAuthorship W2013760089A5049381682 @default.
• W2013760089 hasAuthorship W2013760089A5059651167 @default.
• W2013760089 hasAuthorship W2013760089A5061909361 @default.
• W2013760089 hasAuthorship W2013760089A5071207779 @default.
• W2013760089 hasAuthorship W2013760089A5074661042 @default.
• W2013760089 hasAuthorship W2013760089A5085352453 @default.
• W2013760089 hasAuthorship W2013760089A5091276205 @default.
• W2013760089 hasBestOaLocation W20137600891 @default.
• W2013760089 hasConcept C121608353 @default.
• W2013760089 hasConcept C126322002 @default.
• W2013760089 hasConcept C28328180 @default.
• W2013760089 hasConcept C2908647359 @default.
• W2013760089 hasConcept C502942594 @default.
• W2013760089 hasConcept C55427017 @default.
• W2013760089 hasConcept C555283112 @default.
• W2013760089 hasConcept C71924100 @default.
• W2013760089 hasConcept C86803240 @default.
• W2013760089 hasConcept C95444343 @default.
• W2013760089 hasConcept C99454951 @default.
• W2013760089 hasConceptScore W2013760089C121608353 @default.
• W2013760089 hasConceptScore W2013760089C126322002 @default.
• W2013760089 hasConceptScore W2013760089C28328180 @default.
• W2013760089 hasConceptScore W2013760089C2908647359 @default.
• W2013760089 hasConceptScore W2013760089C502942594 @default.
• W2013760089 hasConceptScore W2013760089C55427017 @default.
• W2013760089 hasConceptScore W2013760089C555283112 @default.

• next