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- W2013770190 abstract "Here we show that extracts of Boswellia serrata gum resins and its constituents, the boswellic acids (BAs), activate the mitogen-activated protein kinases (MAPK) p42MAPK and p38 in isolated human polymorphonuclear leukocytes (PMNL). MAPK activation was rapid and transient with maximal activation after 1–2.5 min of exposure and occurred in a dose-dependent manner. The keto-BAs (11-keto-β-BA and 3-O-acetyl-11-β-keto-BA) gave substantial kinase activation at 30 μM, whereas other BAs lacking the 11-keto group were less effective. Moreover, 11-keto-BAs induced rapid and prominent mobilization of free Ca2+ in PMNL. Inhibitor studies revealed that phosphatidylinositol 3-kinase (PI 3-K) is involved in BA-induced MAPK activation, whereas a minor role was apparent for protein kinase C. MAPK activation by 3-O-acetyl-11-β-keto-BA was partially inhibited when Ca2+ was removed by chelation. Our results suggest that 11-keto-BAs might function as potent activators of PMNL by stimulation of MAPK and mobilization of intracellular Ca2+." @default.
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- W2013770190 date "2002-01-01" @default.
- W2013770190 modified "2023-10-16" @default.
- W2013770190 title "Boswellic Acids Activate p42MAPK and p38 MAPK and Stimulate Ca2+ Mobilization" @default.
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- W2013770190 doi "https://doi.org/10.1006/bbrc.2001.6153" @default.
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