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- W2013771004 abstract "Natural product discovery is pivot for drug development, however, this endeavor is often challenged by the wide inactivation or silence of natural products biosynthetic pathways. We recently developed a highly efficient approach to activate cryptic/silenced biosynthetic pathways through augmentation of the phosphopantetheinylation of carrier proteins. By applying this approach in the Streptomyces alboniger NRRL B-1832, we herein identified three cryptic nucleosides products, including one known puromycin A and two new derivatives (puromycin B and C). The biosynthesis of these products doesn't require the involvement of carrier protein, indicating the phosphopantetheinyl transferase (PPtase) indeed plays a fundamental regulatory role in metabolites biosynthesis. These results demonstrate that the PPtase-based approach have a much broader effective scope than the previously assumed carrier protein-involving pathways, which will benefit future natural products discovery and biosynthetic studies." @default.
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- W2013771004 date "1969-05-01" @default.
- W2013771004 modified "2023-10-18" @default.
- W2013771004 title "Biosynthesis of puromycin in Streptomyces alboniger. Possible precursors of the antibiotic in a commercial sample" @default.
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- W2013771004 doi "https://doi.org/10.1016/0005-2787(69)90539-5" @default.
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