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- W2013771845 abstract "A simple method is proposed for measuring right or left ventricular systolic pressure based on analysis of the right or left ventricular time-activity curve, obtained with a scintillation camera or cardiac probe after intravenous injection of technetium-99m albumin or red blood cells. The method is based on three principles: (1) intraventricular pressure equals force per area of the aortic opening; (2) force equals mass (of blood) times its acceleration; and (3) acceleration can be derived from the ventricular volume curve. The following differential equation was derived where ( is the first derivative of left ventricular pressure; ϱ is the density of blood; A is the area of the aortic opening∗; α is the ratio of blood volume to radioactivity (a) measured within the ventricle, is the first derivative (velocity) of the activity (a) within the véntricle and is the second derivative (acceleration). The integration of this equation is readily accomplished, and the integrated curve reflects the pressure changes. Absolute calibration in millimeters of mercury requires knowledge of the end-diastolic volume and the area of the aortic opening. It is assumed that the area of aortic opening is relatively constant, that blood flow is laminar and that the pressure pulse travels with the velocity of blood through the aortic opening. In validation studies in dogs, calculated and observed ventricular pressure curves were nearly identical in shape and absolute value. In patients, although an absolute pressure measurement still awaits an accurate method for calculation of left ventricular enddiastolic volume, differences in the shape and amplitude of the curves were found. The procedure can be performed easily, and the calculation can be made within minutes. With further validation, the method may provide noninvasively a pressure and volume relation that is valuable in characterizing the function of the heart as a pump, both at rest and during graded exercise." @default.
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- W2013771845 date "1979-09-01" @default.
- W2013771845 modified "2023-09-27" @default.
- W2013771845 title "Noninvasive measurement of ventricular pressure throughout systole" @default.
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- W2013771845 doi "https://doi.org/10.1016/0002-9149(79)90398-9" @default.
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