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- W2013774910 abstract "The Dab1 docking protein is required for the proper organization of brain laminae and for a signal transduction pathway initiated by Reelin binding to the ApoER2 and VLDLR receptors on the cell surface of neurons. Dab1 physically interacts with APP; however, it is not known whether the APP gene influences Dab1 function. Here we demonstrate a genetic interaction between Dab1 and APP. Dab1-hypomorphic animals have neuronal ectopias in the neocortex and reduced cerebellar volume, possibly a consequence of Purkinje cell misplacement. These phenotypes are exacerbated in transgenic animals overexpressing a mutant form of APP, APP(swe), which is characterized by increased processing at the beta-secretase site. The Dab1-hypomorphic phenotype is improved in the cerebellum of animals that are deficient for APP. Together this suggests that APP expression constrains the consequences of Dab1 activity during brain development." @default.
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- W2013774910 date "2008-01-01" @default.
- W2013774910 modified "2023-09-23" @default.
- W2013774910 title "A genetic interaction between the APP and Dab1 genes influences brain development" @default.
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- W2013774910 doi "https://doi.org/10.1016/j.mcn.2007.09.008" @default.
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