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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013785544> ?p ?o ?g. }

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• W2013785544 abstract "The pituitary cell-specific transcription factor Pit-1 has been show to trans-activate expression of the prolactin (PRL) promoter in non-pituitary cells. However, the cyclic AMP response element (CRE)-binding protein CREB is known to play a major role in cell-specific expression of hepatocyte-specific genes. Since the PRL promoter contains an asymmetrical form of a cyclic AMP response element (termed the CLE), we investigated whether CREB could also induce PRL promoter activity in non-pituitary cells. Transient expression in rat glial C6 cells of a constitutively active CREB-VP16 fusion protein strongly trans-activated expression of a co-transfected rat PRL promoter construct, ( −187)PRL-CAT. Analysis by 5'-deletion showed that this response requires PRL promoter sequences between positions −113/ −75. CREB-VP16 did not stimulate expression in C6 cells of any of three control promoter-CAT constructs, implying that the strong response of the PRL promoter to activated CREB is both promoter-specific, and is not due to non-specific transcriptional effects of the potent VP16 moiety of CREB-VP16. Surprisingly, mutations in the CLE only slightly reduced activation by CREB-VP16 of construct (−204)PRL-CAT, implying that the major action of CREB-VP16 on the PRL promoter does not involve a direct interaction with the CLE. CREB-VP16 stimulated PRL-CAT activity in C6 cells as strongly as, and synergistically with, Pit-1. These results imply that CREB can strongly and specifically activate expression of the PRL promoter in non-pituitary cells, via a mechanism different from that employed by Pit-1." @default.
• W2013785544 created "2016-06-24" @default.
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• W2013785544 date "1994-05-01" @default.
• W2013785544 modified "2023-09-25" @default.
• W2013785544 title "A constitutively active form of CREB can activate expression of the rat prolactin promoter in non-pituitary cells" @default.
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• W2013785544 doi "https://doi.org/10.1016/0303-7207(94)90255-0" @default.
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