FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013790136> ?p ?o ?g. }

• W2013790136 endingPage "543" @default.
• W2013790136 startingPage "535" @default.
• W2013790136 abstract "Carbenoxolone (CBX) is a semisynthetic derivative of the licorice root substance glycyrrhizinic acid and has been previously reported to induce only heat shock protein 70 [Hsp70, HSPA1A (the systematic name of heat shock protein is given in the parenthesis after each HSP, according to the recent nomenclature guidelines, Kampinga et al., Cell Stress Chaperones, 14:105–111, 2008) but not other heat shock proteins (HSPs) (Nagayama et al., Life Sci. 69:2867–2873, 2001). In this study, we reinvestigated the effect of CBX on the induction of HSPs in HeLa and human neuroblastoma (A-172) cells. CBX clearly induced not only Hsp70 but also Hsp90 (HSPC1), Hsp40 (DNAJB1), and Hsp27 (HSPB1) at concentrations of 10 to 800 μM for 16 h incubation. At higher concentrations (more than 400 μM), however, CBX appeared to be toxic. Treatment of cells with CBX resulted in enhanced phosphorylation and acquisition of DNA-binding ability of heat shock transcription factor 1 (HSF1). Furthermore, characteristic HSF1 granules were formed in the nucleus, suggesting that the induction of HSPs by CBX is mediated by the activation of HSF1. Furthermore, thermotolerance was induced by CBX treatment, as determined by clonogenic survival. Although the precise target of CBX is not known at present, these results indicate that CBX is one of the molecular chaperone inducers and suggest that some pharmacological activities of CBX might be ascribable in part to its molecular chaperone-inducing property." @default.
• W2013790136 created "2016-06-24" @default.
• W2013790136 creator A5010455322 @default.
• W2013790136 creator A5039334334 @default.
• W2013790136 creator A5042208218 @default.
• W2013790136 creator A5054907130 @default.
• W2013790136 creator A5056869124 @default.
• W2013790136 date "2009-03-31" @default.
• W2013790136 modified "2023-10-14" @default.
• W2013790136 title "Reinvestigation of the effect of carbenoxolone on the induction of heat shock proteins" @default.
• W2013790136 cites W136076975 @default.
• W2013790136 cites W1620035021 @default.
• W2013790136 cites W1932510449 @default.
• W2013790136 cites W1966923623 @default.
• W2013790136 cites W1967138582 @default.
• W2013790136 cites W1971892384 @default.
• W2013790136 cites W1973328141 @default.
• W2013790136 cites W1987404531 @default.
• W2013790136 cites W1995249229 @default.
• W2013790136 cites W2000868368 @default.
• W2013790136 cites W2003666655 @default.
• W2013790136 cites W2014044948 @default.
• W2013790136 cites W2023456736 @default.
• W2013790136 cites W2028131204 @default.
• W2013790136 cites W2031540128 @default.
• W2013790136 cites W2036575964 @default.
• W2013790136 cites W2043898595 @default.
• W2013790136 cites W2044930326 @default.
• W2013790136 cites W2046095499 @default.
• W2013790136 cites W2046654353 @default.
• W2013790136 cites W2049617712 @default.
• W2013790136 cites W2051920652 @default.
• W2013790136 cites W2054626405 @default.
• W2013790136 cites W2063956958 @default.
• W2013790136 cites W2075341017 @default.
• W2013790136 cites W2089400513 @default.
• W2013790136 cites W2094782116 @default.
• W2013790136 cites W2096966529 @default.
• W2013790136 cites W2104344784 @default.
• W2013790136 cites W2112140076 @default.
• W2013790136 cites W2115616939 @default.
• W2013790136 cites W2119624960 @default.
• W2013790136 cites W2125284637 @default.
• W2013790136 cites W2148573587 @default.
• W2013790136 cites W2154429929 @default.
• W2013790136 cites W2160035649 @default.
• W2013790136 cites W2225701798 @default.
• W2013790136 cites W33124323 @default.
• W2013790136 cites W34419869 @default.
• W2013790136 doi "https://doi.org/10.1007/s12192-009-0106-0" @default.
• W2013790136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2728286" @default.
• W2013790136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19333787" @default.
• W2013790136 hasPublicationYear "2009" @default.
• W2013790136 type Work @default.
• W2013790136 sameAs 2013790136 @default.
• W2013790136 citedByCount "17" @default.
• W2013790136 countsByYear W20137901362013 @default.
• W2013790136 countsByYear W20137901362014 @default.
• W2013790136 countsByYear W20137901362015 @default.
• W2013790136 countsByYear W20137901362017 @default.
• W2013790136 countsByYear W20137901362018 @default.
• W2013790136 countsByYear W20137901362020 @default.
• W2013790136 countsByYear W20137901362021 @default.
• W2013790136 countsByYear W20137901362022 @default.
• W2013790136 crossrefType "journal-article" @default.
• W2013790136 hasAuthorship W2013790136A5010455322 @default.
• W2013790136 hasAuthorship W2013790136A5039334334 @default.
• W2013790136 hasAuthorship W2013790136A5042208218 @default.
• W2013790136 hasAuthorship W2013790136A5054907130 @default.
• W2013790136 hasAuthorship W2013790136A5056869124 @default.
• W2013790136 hasBestOaLocation W20137901362 @default.
• W2013790136 hasConcept C104317684 @default.
• W2013790136 hasConcept C137984847 @default.
• W2013790136 hasConcept C158157758 @default.
• W2013790136 hasConcept C185592680 @default.
• W2013790136 hasConcept C205260736 @default.
• W2013790136 hasConcept C2776667301 @default.
• W2013790136 hasConcept C2779559962 @default.
• W2013790136 hasConcept C2780961449 @default.
• W2013790136 hasConcept C55493867 @default.
• W2013790136 hasConcept C68991219 @default.
• W2013790136 hasConcept C79879829 @default.
• W2013790136 hasConcept C86803240 @default.
• W2013790136 hasConcept C95444343 @default.
• W2013790136 hasConceptScore W2013790136C104317684 @default.
• W2013790136 hasConceptScore W2013790136C137984847 @default.
• W2013790136 hasConceptScore W2013790136C158157758 @default.
• W2013790136 hasConceptScore W2013790136C185592680 @default.
• W2013790136 hasConceptScore W2013790136C205260736 @default.
• W2013790136 hasConceptScore W2013790136C2776667301 @default.
• W2013790136 hasConceptScore W2013790136C2779559962 @default.
• W2013790136 hasConceptScore W2013790136C2780961449 @default.
• W2013790136 hasConceptScore W2013790136C55493867 @default.
• W2013790136 hasConceptScore W2013790136C68991219 @default.
• W2013790136 hasConceptScore W2013790136C79879829 @default.
• W2013790136 hasConceptScore W2013790136C86803240 @default.
• W2013790136 hasConceptScore W2013790136C95444343 @default.
• W2013790136 hasIssue "5" @default.

• next